Evidence map›Paper›PMID 30897999›Full record

Trial reportJournal of the American Heart Association2019

Cardiovascular and Lifestyle Risk Factors and Cognitive Function in Patients With Stable Coronary Heart Disease.

Ralph A H Stewart, Claes Held, Sue Krug-Gourley, Dawn Waterworth, Amanda Stebbins, Karen Chiswell, Emil Hagstrom, Paul W Armstrong, Lars Wallentin, Harvey White

Open access · goldAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Journal of the American Heart Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 50 citations in OpenAlex.

  1. Trial
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  6. Personality and Cognition: The Mediating Role of Inflammatory Markers.The journals of gerontology. Series B, Psychological sciences and social sciences · 2024
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  15. Blood pressure, executive function, and network connectivity in middle-aged adults at risk of dementia in late life.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 5 countries.

Ralph A H Stewart1 Green Lane Cardiovascular Service Auckland City Hospital Auckland New Zealand.
Claes Held3 Department of Medical Sciences Cardiology Uppsala University Uppsala Sweden.
Sue Krug-Gourley5 Metabolic Pathways and Cardiovascular Medicine Delivery Unit GlaxoSmithKline Research and Development Collegeville PA.
Dawn Waterworth6 Department of Genetics GlaxoSmithKline Medicines Research Centre Upper Merion Philadelphia PA.
Amanda Stebbins7 Duke Clinical Research Institute Durham NC.
Karen Chiswell7 Duke Clinical Research Institute Durham NC.
Emil Hagstrom3 Department of Medical Sciences Cardiology Uppsala University Uppsala Sweden.
Paul W Armstrong8 Canadian VIGOUR Centre University of Alberta Edmonton Canada.
Lars Wallentin3 Department of Medical Sciences Cardiology Uppsala University Uppsala Sweden.
Harvey White1 Green Lane Cardiovascular Service Auckland City Hospital Auckland New Zealand.
Uppsala University · SEClinical Research Institute · USAuckland City Hospital · NZCanadian VIGOUR Centre · CAGlaxoSmithKline (United Kingdom) · GBPathways Behavioral Services · USUniversity of Auckland · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background Vascular risk factors have been associated with differences in cognitive performance in epidemiological studies, but evidence in patients with coronary heart disease is more limited. Methods and Results The Montreal Cognitive Assessment score obtained 3.2±0.37 years after randomization to darapladib, a reversible inhibitor of lipoprotein phospholipase A

Indexed as

AgedBenzaldehydesBiphenyl CompoundsCardiovascular DiseasesCognitionCognitive DysfunctionCoronary DiseaseDiethylaminesExerciseFemaleHumansMaleMiddle AgedOximesPhospholipase A2 InhibitorsPyrimidinonesBenzaldehydesBiphenyl CompoundsdarapladibDiethylaminesOximesPhospholipase A2 InhibitorsPyrimidinonesSulfidescognitive impairmentcoronary heart diseaseMontreal Cognitive Assessmentrisk factor

Identifiers

PMID30897999
PMCPMC6509727
OpenAlexW2923488432

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.