Evidence map›Paper›PMID 30897936›Full record

ArticleCartilage2021

Intermittent Parathyroid Hormone [1-34] Augments Chondrogenesis of the Mandibular Condylar Cartilage of the Temporomandibular Joint.

Eliane H Dutra, Mara H O'Brien, Po-Jung Chen, Mei Wei, Sumit Yadav

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cartilage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Eliane H DutraDivision of Orthodontics, University of Connecticut Health Center, Farmington, CT, USA.
Mara H O'BrienDivision of Orthodontics, University of Connecticut Health Center, Farmington, CT, USA.
Po-Jung ChenDivision of Orthodontics, University of Connecticut Health Center, Farmington, CT, USA.
Mei WeiUCONN School of Engineering, University of Connecticut, Storrs, CT, USA.
Sumit YadavDivision of Orthodontics, University of Connecticut Health Center, Farmington, CT, USA.ORCID 0000-0002-2434-7995
UConn Health · USUniversity of Connecticut · US

Funding

Mechanism of BMP2 regulation of Mandibular Condylar Cartilage GrowthK08DE025914 · NIDCR · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI YADAV, SUMIT · 2017 to 2021
$947k
The role of FGFR3 in the effects of PTH in the Mandibular CondyleK01DE029528 · NIDCR · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI DUTRA, ELIANE · 2020 to 2024
$934k
NIDCR NIH HHS K01 DE029528NIDCR NIH HHS K08 DE025914
6 · The paper itself

Abstract

objectiveTo characterize the long-term effects of intermittent parathyroid hormone (I-PTH) on the mandibular condylar cartilage (MCC) and subchondral bone of the temporomandibular joint, MATERIALS AND

methodsFor the

resultsThere was a significant increase in bone volume, tissue density, mineral deposition, osteoclastic activity, cell proliferation in the cartilage, and cartilage thickness in the I-PTH-treated mice when compared with the control group. In addition, immunohistochemistry in cartilage revealed that I-PTH administration led to an increase in expression of vascular endothelial growth factor and to a decreased expression of sclerostin, matrix metallopeptidase 13, and aggreganase-1 (ADAM-TS4). Quantitative polymerase chain reaction analysis of the I-PTH-treated chondrocytes revealed significantly decreased relative expression of collagen type X (

conclusionI-PTH administration causes anabolic effects at the subchondral region of the mandibular condyle while triggers anabolic and protective effects at the MCC.

Indexed as

ChondrogenesisMandibular CondyleAnimalsCartilageHedgehog ProteinsMiceParathyroid HormoneTemporomandibular JointVascular Endothelial Growth Factor AHedgehog ProteinsParathyroid HormoneVascular Endothelial Growth Factor Amandibular condylar cartilageparathyroid hormonetemporomandibular joint

Identifiers

PMID30897936
PMCPMC8461153
OpenAlexW2922998527

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.