Evidence map›Paper›PMID 30897836›Full record

ArticleMolecules (Basel, Switzerland)2019

Preparation of Sesquiterpene Lactone Derivatives: Cytotoxic Activity and Selectivity of Action.

María F Beer, Augusto E Bivona, Andrés Sánchez Alberti, Natacha Cerny, Guillermo F Reta, Víctor S Martín, José M Padrón, Emilio L Malchiodi, Valeria P Sülsen, Osvaldo J Donadel

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. ACS omega · 2022
    Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

María F BeerINTEQUI-CONICET, Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, Almirante Brown 1445, CP D5700HGC, San Luis, Argentina. mflorenciabeer@gmail.com.
Augusto E BivonaCátedra de Inmunología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956 2°P (1113), Buenos Aires, Argentina. augustobivona@gmail.com.
Andrés Sánchez AlbertiCátedra de Inmunología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956 2°P (1113), Buenos Aires, Argentina. andres.sanchez.alberti@gmail.com.
Natacha CernyCONICET-Universidad Nacional de Luján, Instituto de Ecología y Desarrollo Sustentable (INEDES), Ruta 5 y Avenida Constitución-(6700), Luján, Argentina. natachacerny@gmail.com.
Guillermo F RetaINTEQUI-CONICET, Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, Almirante Brown 1445, CP D5700HGC, San Luis, Argentina. gfreta@gmail.com.
Víctor S MartínInstituto Universitario de Bio-Orgánica Antonio González (IUBO-AG), Universidad de La Laguna, Avda. Astrofísico Francisco Sánchez 2, 38206 La Laguna, Spain. vmartin@ull.es.
José M PadrónInstituto Universitario de Bio-Orgánica Antonio González (IUBO-AG), Universidad de La Laguna, Avda. Astrofísico Francisco Sánchez 2, 38206 La Laguna, Spain. jmpadron@ull.es.
Emilio L MalchiodiCátedra de Inmunología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956 2°P (1113), Buenos Aires, Argentina. emalchio@ffyb.uba.ar.
Valeria P SülsenCONICET-Universidad de Buenos Aires. Instituto de Química y Metabolismo del Fármaco (IQUIMEFA), Junín 956 2°P (1113), Buenos Aires, Argentina. vsulsen@ffyb.uba.ar.
Osvaldo J DonadelINTEQUI-CONICET, Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, Almirante Brown 1445, CP D5700HGC, San Luis, Argentina. odonadel@gmail.com.

Funding

Agencia Nacional de Promoción Científica y Tecnológica PICT 2015-3531Consejo Nacional de Investigaciones Científicas y Técnicas PIP-090Consejo Nacional de Investigaciones Científicas y Técnicas PIP 11220150100158COUniversidad de Buenos Aires UBACYT 20020130200270Universidad Nacional de San Luis PROICO 2-2516
6 · The paper itself

Abstract

Cancer is one of the most important causes of death worldwide. Solid tumors represent the great majority of cancers (>90%) and the chemotherapeutic agents used for their treatment are still characterized by variable efficacy and toxicity. Sesquiterpene lactones are a group of naturally occurring compounds that have displayed a diverse range of biological activities including cytotoxic activity. A series of oxygenated and oxy-nitrogenated derivatives (

Indexed as

Antineoplastic Agents, PhytogenicCell Line, TumorCell ProliferationColonic NeoplasmsHumansLactonesSesquiterpenesSesquiterpenes, GuaianeAntineoplastic Agents, PhytogenichelenalinLactonesSesquiterpenesSesquiterpenes, Guaianeantiproliferative activityAsteraceaecumaninhelenalinhymeninsesquiterpene lactones

Identifiers

PMID30897836
PMCPMC6471591

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.