ReviewInternational journal of molecular sciences2019
Periodontal Disease: A Risk Factor for Diabetes and Cardiovascular Disease.
Review in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06486012 (Regular Use of Antibacterial Photodynamic Therapy in the Management and Prevention of Periodontitis Symptoms in Diabetic Patients - Special Attention to Diabetic Balance and Metabolism), which is not on this map. Cited by 271 papers, 12 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Regular Use of Antibacterial Photodynamic Therapy in the Management and Prevention of Periodontitis Symptoms in Diabetic Patients - Special Attention to Diabetic Balance and Metabolism
Who cites it
271 citing papers in PubMed, 12 syntheses or guidelines pooled it, 494 citations in OpenAlex.
- Is There Any Association Between Periodontitis and Prostatic Alterations? A Systematic Review.The Prostate · 2025Pooled it
- Association of periodontal disease with the prognosis of chronic kidney disease: A meta-analysis.Journal of the Chinese Medical Association : JCMA · 2025Pooled it
- Anti-Porphyromonas gingivalis Antibody Levels in Patients With Stroke and Atrial Fibrillation: A Systematic Review and Meta-Analysis.Clinical and experimental dental research · 2024Pooled it
- Is there an association between periodontal disease and infertility? A systematic review.Medicina oral, patologia oral y cirugia bucal · 2024Pooled it
- Periodontitis and the risk of oral cancer: a meta-analysis of case-control studies.Acta odontologica Scandinavica · 2024Pooled it
- Comparison of the clinical efficacy of bone grafting and bone grafting combined with guided tissue regeneration in periodontal regenerative therapy: a meta-analysis.Acta odontologica Scandinavica · 2024Pooled it
- Systemic benefits of periodontal therapy in patients with obesity and periodontitis: a systematic review.Brazilian oral research · 2024Pooled it
- Stem cell-based therapy in periodontal regeneration: a systematic review and meta-analysis of clinical studies.BMC oral health · 2023Pooled it
- Oral frailty indicators to target major adverse health-related outcomes in older age: a systematic review.GeroScience · 2023Pooled it
- Is There an Association Between Parkinson's Disease and Periodontitis? A Systematic Review and Meta-Analysis.Journal of Parkinson's disease · 2023Pooled it
- Periodontal disease and subsequent risk of cardiovascular outcome and all-cause mortality: A meta-analysis of prospective studies.PloS one · 2023Pooled it
- Periodontal Disease in Patients with Psoriasis: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- Effects of an Oral Health Management Program During Pregnancy: A Randomized Controlled Trial.Oral diseases · 2026Trial
- Association between periodontitis and subclinical vascular dysfunction: a systematic review and meta-analysis.Odontology · 2026Review
- Association of Subjective Oral Status and Oral Health Behaviours With a History of Systemic Disease Among Community-Dwelling Older Adults.Oral health & preventive dentistry · 2026Article
- Root morphology and alveolar bone phenotype of maxillary second molars in patients with periodontitis: a cross-sectional study.BMC oral health · 2026Article
- Association Between Glyco-Lipid Seven-Factor Index, a Novel Composite Glyco-Lipid Index, and Periodontitis: A Cross-Sectional Study.International dental journal · 2026Article
- Association ofJournal of clinical medicine · 2026Review
- Tobacco-Induced Oral Dysbiosis and Microbial Shifts: A Narrative Review of Their Role in Systemic Inflammation and Disease.Microorganisms · 2026Review
- Artificial intelligence in periodontal disease research: a bibliometric and visualized analysis of global research trends (2007-2025).The Saudi dental journal · 2026Review
211 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
Periodontitis is a chronic inflammatory disease, initiated by the presence of a bacterial biofilm, called dental plaque, which affects both the periodontal ligaments and bone surrounding teeth. In the last decades, several lines of evidence have supported the existence of a relationship between periodontitis and systemic health. For instance, as periodontitis acts within the same chronic inflammatory model seen in cardiovascular disease (CVD), or other disorders, such as diabetes, several studies have suggested the existence of a bi-directional link between periodontal health and these pathologies. For instance, people with diabetes are more susceptible to infections and are more likely to suffer from periodontitis than people without this syndrome. Analogously, it is now evident that cardiac disorders are worsened by periodontitis, both experimentally and in humans. For all these reasons, it is very plausible that preventing periodontitis has an impact on the onset or progression of CVD and diabetes. On these grounds, in this review, we have provided an updated account on the current knowledge concerning periodontal disease and the adverse effects exerted on the cardiovascular system health and diabetes, informing readers on the most recent preclinical studies and epidemiological evidence.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.