ReviewNutrients2019
Effects of Drugs and Excipients on Hydration Status.
Review in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05380089 (Effects of Hydration Changes on Neuromuscular Function of Athletes With Low Water Intake), which is not on this map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Hydration Changes on Neuromuscular Function of Athletes With Low Water Intake
Who cites it
20 citing papers in PubMed, 52 citations in OpenAlex.
- Individual-level Factors Associated With Acute Hospitalization After Medically Attended Acute Gastroenteritis and Norovirus Gastroenteritis in the United States, 2022-2024.Open forum infectious diseases · 2026Article
- Identification of potentially heat-vulnerability increasing drugs - a narrative review.European journal of clinical pharmacology · 2026Review
- Exploring Staff Perspectives on the Feasibility of Integrating the Environmental Components of a Novel Intervention for Hydration in Long-Term Care.International journal of older people nursing · 2026Article
- Review
- Silent Dangers in Elderly Pharmacotherapy: The Interplay of Polypharmacy, Multimorbidity, and Drug Interactions.Journal of evaluation in clinical practice · 2025Review
- Hydration Strategies in Older Adults.Nutrients · 2025Review
- Exploring Intervention Strategies to Prevent Occupational Heat Stress. A Scoping Review.Safety and health at work · 2025Review
- Effect of fluid intake on cognitive function in older individuals: A prospective study.PloS one · 2025Article
- Article
- Climate change's implications for practice: Pharmacologic considerations of heat-related illness.The Nurse practitioner · 2024Article
- Drug Consumption and Hydration Status: Analysis of the Associations in an Elder Population.Nutrients · 2024Article
- Assessing skeletal muscle mass and lean body mass: an analysis of the agreement among dual X-ray absorptiometry, anthropometry, and bioelectrical impedance.Frontiers in nutrition · 2024Article
- Validity and agreement between dual-energy X-ray absorptiometry, anthropometry and bioelectrical impedance in the estimation of fat mass in young adults.Frontiers in nutrition · 2024Article
- A North American prospective study of depression, psychotropic medication use, and semen quality.Fertility and sterility · 2021Article
- Heat Safety in the Workplace: Modified Delphi Consensus to Establish Strategies and Resources to Protect the US Workers.GeoHealth · 2021Article
- Article
- Effect of Stand-Up Paddle Boarding on Hydration Status in Recreational and Competitive Individuals.International journal of exercise science · 2021Article
- Ethanolic Extract ofMolecules (Basel, Switzerland) · 2020Article
- Pharmacological Interactions in the Elderly.Medicina (Kaunas, Lithuania) · 2020Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Despite being the most essential nutrient, water is commonly forgotten in the fields of pharmacy and nutrition. Hydration status is determined by water balance (the difference between water input and output). Hypohydration or negative water balance is affected by numerous factors, either internal (i.e., a lack of thirst sensation) or external (e.g., polypharmacy or chronic consumption of certain drugs). However, to date, research on the interaction between hydration status and drugs/excipients has been scarce. Drugs may trigger the appearance of hypohydration by means of the increase of water elimination through either diarrhea, urine or sweat; a decrease in thirst sensation or appetite; or the alteration of central thermoregulation. On the other hand, pharmaceutical excipients induce alterations in hydration status by decreasing the gastrointestinal transit time or increasing the gastrointestinal tract rate or intestinal permeability. In the present review, we evaluate studies that focus on the effects of drugs/excipients on hydration status. These studies support the aim of monitoring the hydration status in patients, mainly in those population segments with a higher risk, to avoid complications and associated pathologies, which are key axes in both pharmaceutical care and the field of nutrition.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.