Evidence map›Paper›PMID 30897686›Full record

Trial reportNutrients2019

PHAGE Study: Effects of Supplemental Bacteriophage Intake on Inflammation and Gut Microbiota in Healthy Adults.

Hallie P Febvre, Sangeeta Rao, Melinda Gindin, Natalie D M Goodwin, Elijah Finer, Jorge S Vivanco, Shen Lu, Daniel K Manter, Taylor C Wallace, Tiffany L Weir

2 registry-linked trialsOpen access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 127 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
127citing papers in PubMed, 2 pooled it
6.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03269617 nacompletednot on this map

PreforPro: A Randomized, Placebo Controlled Crossover Study

TypeinterventionalSponsorColorado State UniversityRan2016 to 2017Enrolled43ConditionsGastrointestinal Disorder, FunctionalArmsBacteriophage mixture, Placebo Control
NCT05750433 nacompletednot on this mapstarted 2021, after this paper: background citation

PHAGE 3: Determination of Phage and Probiotic Synergistic Effects on Gastrointestinal Health

TypeinterventionalSponsorColorado State UniversityRan2021 to 2024Enrolled120ConditionsGastrointestinal DysfunctionArmsPreforPro+B. subtilis DE111 probiotics, Placebo, B. subtilis DE111
3 · Its place in the literature

Who cites it

127 citing papers in PubMed, 2 syntheses or guidelines pooled it, 177 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Beneficial microbes · 2020
    Trial
  6. Trial
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Phage Therapy in Gastrointestinal Diseases: Current Status and Challenges.International journal of molecular sciences · 2026
    Review
  15. Article
  16. Review
  17. Isolation and Characterization of aAntibiotics (Basel, Switzerland) · 2026
    Article
  18. Article
  19. Article
  20. Review

67 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Hallie P FebvreDepartment of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO 80523, USA. Hallie.Febvre@colostate.edu.
Sangeeta RaoDepartment of Clinical Sciences, Colorado State University, Fort Collins, CO 80523, USA. sangeeta.rao@colostate.edu.
Melinda GindinDepartment of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO 80523, USA. melinda@stillwater.life.
Natalie D M GoodwinDepartment of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO 80523, USA. natalie.goodwin@colostate.edu.
Elijah FinerDepartment of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO 80523, USA. elijah.finer@colostate.edu.
Jorge S VivancoPolaris Expeditionary Learning School, Fort Collins, CO 80525, USA. 91929@psdschools.org.
Shen LuDepartment of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO 80523, USA. shen.lu2017@hotmail.com.
Daniel K ManterSoil Management and Sugarbeet Research, ARS, USDA, Fort Collins, CO 80523, USA. daniel.manter@ars.usda.gov.
Taylor C WallaceThink Healthy Group, Inc., Washington, DC 20001, USA. taylor.wallace@me.com.
Tiffany L WeirDepartment of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO 80523, USA. tiffany.weir@colostate.edu.
Colorado State University · USAgricultural Research Service · USGeorge Mason University · USPolaris (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The gut microbiota is increasingly recognized as an important modulator of human health. As such, there is a growing need to identify effective means of selectively modifying gut microbial communities. Bacteriophages, which were briefly utilized as clinical antimicrobials in the early 20th century, present an opportunity to selectively reduce populations of undesirable microorganisms. However, whether intentional consumption of specific bacteriophages affects overall gut ecology is not yet known. Using a commercial cocktail of

Indexed as

ColiphagesAdolescentAdultAgedDietary SupplementsDouble-Blind MethodEscherichia coliFemaleGastrointestinal DiseasesGastrointestinal MicrobiomeHumansInflammationLipidsMaleMiddle AgedYoung AdultLipidsbacteriophagecytokinesgastrointestinalgut microbiotainflammationshort-chain fatty acid

Identifiers

PMID30897686
PMCPMC6471193
OpenAlexW2924638868

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.