Evidence map›Paper›PMID 30897573›Full record

SynthesisFetal diagnosis and therapy2019

Amnioinfusions to Treat Early Onset Anhydramnios Caused by Renal Anomalies: Background and Rationale for the Renal Anhydramnios Fetal Therapy Trial.

Elizabeth M O'Hare, Angie C Jelin, Jena L Miller, Rodrigo Ruano, Meredith A Atkinson, Ahmet A Baschat, Eric B Jelin

2 registry-linked trialsOpen access · bronzeAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Fetal diagnosis and therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03101891 phase1completednot on this map

Renal Anhydramnios Fetal Therapy (RAFT) Trial

TypeinterventionalSponsorJohns Hopkins UniversityRan2018 to 2026Enrolled55ConditionsAnhydramnios, Potter Syndrome, Lung Hypoplasia, Multicystic Dysplastic KidneyArmsSerial amnioinfusions with isotonic fluid, Spinal needle, Isotonic fluid
NCT06728228 narecruitingnot on this mapstarted 2024, after this paper: background citation

Amnioinfusion for Fetal Renal Failure

TypeinterventionalSponsorFetal Care Center, PLLCRan2024 to 2026Enrolled35ConditionsMulticystic Dysplastic Kidney, Polycystic Kidney Disease, Fetal Renal Anomaly, AnhydramniosArmsAmnioinfusion
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Bilateral renal agenesis: fetal intervention and outcomes.Pediatric nephrology (Berlin, Germany) · 2025
    Review
  5. Article
  6. Article
  7. Prenatally-diagnosed renal failure: an ethical framework for decision-making.Journal of perinatology : official journal of the California Perinatal Association · 2024
    Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Elizabeth M O'HareJohns Hopkins University, Baltimore, Maryland, USA.
Angie C JelinGynecology and Obstetrics, Johns Hopkins University, Baltimore, Maryland, USA.
Jena L MillerGynecology and Obstetrics, Johns Hopkins University, Baltimore, Maryland, USA.
Rodrigo RuanoObstetrics and Gynecology, Mayo Clinic, Rochester, Minnesota, USA.
Meredith A AtkinsonPediatrics, Johns Hopkins University, Baltimore, Maryland, USA.
Ahmet A BaschatGynecology and Obstetrics, Johns Hopkins University, Baltimore, Maryland, USA.
Eric B JelinPediatric Surgery, Johns Hopkins University, Baltimore, Maryland, USA, ejelin1@jhmi.edu.
Johns Hopkins University · USMayo Clinic · US

Funding

Single gene pathogenic variants associated with BEEC (Bladder Exstrophy, Epispadias, Complex)K23DK119949 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI JELIN, ANGIE CHILD · 2019 to 2023
$1.1M
NIDDK NIH HHS K23 DK119949
6 · The paper itself

Abstract

Anhydramnios caused by early anuria is thought to be universally fatal due to pulmonary hypoplasia. Bilateral renal agenesis and early fetal renal failure leading to anhydramnios constitute early pregnancy renal anhydramnios (EPRA). There have been successful reports of amnioinfusions to promote lung growth in the setting of EPRA. Some of these successfully treated EPRA fetuses have survived the neonatal period, undergone successful dialysis, and subsequently received a kidney transplant. Conversely, there are no reports of untreated EPRA survivors. This early success of amnioinfusions to treat EPRA justifies a rigorous prospective trial. The objective of this study is to provide a review of what is known about fetal therapy for EPRA and describe the Renal Anhydramnios Fetal Therapy trial. We review the epidemiology, pathophysiology, and genetics of EPRA. Furthermore, we have performed systematic review of case reports of treated EPRA. We describe the ethical framework, logistical challenges, and rationale for the current single center (NCT03101891) and planned multicenter trial.

Indexed as

AnuriaFemaleFetal DiseasesFetal TherapiesHumansKidneyKidney DiseasesLungPregnancyAmnioinfusionsAnhydramniosBilateral renal agenesisPulmonary hypoplasiaRenal replacement therapy

Identifiers

PMID30897573
PMCPMC8577736
OpenAlexW2922863352

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.