Evidence map›Paper›PMID 30897363›Full record

ArticleNeuron2019

Inflaming the Brain.

Hyung Jin Ahn, Sarah K Baker, Erin H Norris, Sidney Strickland

Abstract readComment
PubMed Publisher
In one paragraph

Article in Neuron, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Fibrin-Targeting Immunotherapy for Dementia.The journal of prevention of Alzheimer's disease · 2023
    Article
  3. Review
  4. Review
  5. The plasminogen receptor, Plg-RCell death & disease · 2020
    Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Hyung Jin AhnDepartment of Pharmacology, Physiology and Neurosciences, Rutgers-New Jersey Medical School, Newark, NJ 07103, USA; Brain Health Institute, Rutgers University, Piscataway, NJ 08854, USA.
Sarah K BakerPatricia and John Rosenwald Laboratory of Neurobiology and Genetics, The Rockefeller University, New York, NY 10065, USA.
Erin H NorrisPatricia and John Rosenwald Laboratory of Neurobiology and Genetics, The Rockefeller University, New York, NY 10065, USA.
Sidney StricklandPatricia and John Rosenwald Laboratory of Neurobiology and Genetics, The Rockefeller University, New York, NY 10065, USA. Electronic address: strickland@rockefeller.edu.

Funding

Studying Pathogenic Mechanism of Hereditary Cerebral Amyloid AngiopathyR01NS104386 · NINDS · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI AHN, HYUNG JIN · 2018 to 2023
$2.1M
NINDS NIH HHS R01 NS104386
6 · The paper itself

Abstract

Exactly how cerebrovascular alterations contribute to Alzheimer's disease (AD) is still unknown. Merlini et al. (2019) show that blood-derived fibrinogen leads to dendritic spine elimination and cognitive deficit via microglial CD11b/CD18. Fibrinogen may be a significant contributor to AD pathogenesis.

Indexed as

Alzheimer DiseaseCognitive DysfunctionBrainFibrinogenHumansMicrogliaFibrinogen

Identifiers

PMID30897363

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.