ArticleAllergy2019
Vagus nerve stimulation dampens intestinal inflammation in a murine model of experimental food allergy.
Article in Allergy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 43 citations in OpenAlex.
- Food allergy-induced anaphylaxis impairs adrenal adrenergic biosynthesis despite preserved vagal afferent-adrenal sympathetic reflex function.The journal of physiological sciences : JPS · 2026Article
- Review
- Neuroimmune Interactions in Inflammatory Skin and Intestinal Diseases.Journal of inflammation research · 2026Review
- Gut sensory neurons as regulators of neuro-immune-microbial interactions: from molecular mechanisms to precision therapy for IBD/IBS.Journal of neuroinflammation · 2025Review
- Neuroregulatory and clinical efficacy of auricular vagus nerve stimulation in elderly patients with chronic insomnia comorbid with functional dyspepsia: protocol for a randomized controlled trial.Frontiers in medicine · 2025Article
- The molecular components of the anti-inflammatory cholinergic pathway are extrasplenic.PloS one · 2025Article
- Review
- Atopic dermatitis and food allergy: More than sensitization.Mucosal immunology · 2024Review
- Neuroimmune Interactions in the Intestine.Annual review of immunology · 2024Review
- Vagus Nerve Stimulation and Inflammation in Cardiovascular Disease: A State-of-the-Art Review.Journal of the American Heart Association · 2023Review
- Article
- Ion channel regulation of gut immunity.The Journal of general physiology · 2023Article
- Neuroimmune regulation in Hirschsprung's disease associated enterocolitis.Frontiers in immunology · 2023Review
- Dual effects of supplemental oxygen on pulmonary infection, inflammatory lung injury, and neuromodulation in aging and COVID-19.Free radical biology & medicine · 2022Review
- Anatomical variation and distribution of the vagus nerve in the esophageal hiatus: a cross-sectional study of post-mortem cases in Uganda.Surgical and radiologic anatomy : SRA · 2021Article
- Bioelectronics in the brain-gut axis: focus on inflammatory bowel disease (IBD).International immunology · 2021Review
- The intestinal neuro-immune axis: crosstalk between neurons, immune cells, and microbes.Mucosal immunology · 2021Review
- A Focused Review of Neural Recording and Stimulation Techniques With Immune-Modulatory Targets.Frontiers in immunology · 2021Review
- Vagus Nerve Stimulation Promotes Epithelial Proliferation and Controls Colon Monocyte Infiltration During DSS-Induced Colitis.Frontiers in medicine · 2021Article
- Probiotic Interventions Alleviate Food Allergy Symptoms Correlated With Cesarean Section: A Murine Model.Frontiers in immunology · 2021Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe vagus nerve has emerged as an important modulator of the intestinal immune system. Its anti-inflammatory properties have been previously shown in innate and Th1/Th17 predominant inflammatory models. To what extent the vagus nerve is of importance in Th2 inflammatory responses like food allergy is still unclear. In this study, we therefore aimed to investigate the effect of vagotomy (VGX) and vagus nerve stimulation (VNS), on the development and severity of experimental food allergy.
methodsBalb/C mice were first sensitized with ovalbumin (OVA) in the presence of alum. Prior to oral challenges with OVA, mice were subjected to VGX or VNS. Disease severity was determined by assessing severity and onset of diarrhoea, OVA-specific antibody production, mast cell number and activity, inflammatory gene expression in duodenal tissue and lamina propria immune cells by flow cytometry analysis.
resultsWhen compared to control mice, VGX did not significantly affect the development and severity of the disease in our model of food allergy. VNS, on the other hand, resulted in a significant amelioration of the different inflammatory parameters assessed. This effect was independent of α7nAChR and is possibly mediated through the dampening of mast cells and increased phagocytosis of OVA by CX3CR1
conclusionsThese results underscore the anti-inflammatory properties of the vagus nerve and the potential of neuro-immune interactions in the intestine. Further insight into the underlying mechanisms could ultimately lead to novel therapeutic approaches in the treatment of not only food allergy but also other immune-mediated diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.