ArticlePloS one2019
More than an "inverted-U"? An exploratory study of the association between the catechol-o-methyltransferase gene polymorphism and executive functions in Parkinson's disease.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Catechol-O-methyltransferase gene Val158Met polymorphism and obsessive compulsive disorder susceptibility: a meta-analysis.Metabolic brain disease · 2020Pooled it
- Individual differences in learning and decision-making: the role of COMT Val158Met polymorphism in transitive inference.Experimental brain research · 2026Article
- A proof-of-concept study: investigating the impact of COMT genotype and proline on negative symptoms in Alzheimer's disease.BJPsych open · 2025Article
- The Vestibulo-Ocular Reflex is Associated With Visuospatial Dysfunction in Patients With Parkinson's Disease.Brain and behavior · 2025Article
- The Correlation Between RIN3 Gene Methylation and Cognitive Impairment in Parkinson's Disease.Neuropsychiatric disease and treatment · 2025Article
- Disgust-specific impairment of facial emotion recognition in Parkinson's disease patients with mild cognitive impairment.Social cognitive and affective neuroscience · 2024Article
- Brain Glucose Metabolism andDiagnostics (Basel, Switzerland) · 2024Article
- GBA moderates cognitive reserve's effect on cognitive function in patients with Parkinson's disease.Journal of neurology · 2024Article
- Article
- Assessment tools for cognitive performance in Parkinson's disease and its genetic contributors.Frontiers in neurology · 2024Article
- Executive Functions and Public Health: A Narrative Review.Iranian journal of public health · 2023Review
- Genetic Insights into the Molecular Pathophysiology of Depression in Parkinson's Disease.Medicina (Kaunas, Lithuania) · 2023Review
- Investigating the interaction between neuropsychiatry features and daily activities on social function in patients with Parkinson's disease with mild cognitive impairment.BJPsych open · 2022Article
- Mild cognitive impairment in patients with Parkinson's disease: An updated mini-review and future outlook.Frontiers in aging neuroscience · 2022Review
- Dopamine effects on memory load and distraction during visuospatial working memory in cognitively normal Parkinson's disease.Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition · 2021Article
- Review
- Interactions of COMT and ALDH2 Genetic Polymorphisms on Symptoms of Parkinson's Disease.Brain sciences · 2021Article
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5 authors.
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Abstract
Executive dysfunction is common in Parkinson's disease (PD) patients. The catechol-O-methyltransferase (COMT) Val158Met polymorphism has been proposed to affect executive functions (EFs) in the prefrontal cortex. The present study attempted to explore the influence of the COMT polymorphism on EFs in patients with PD. Fifty-four PD patients were recruited and underwent neuropsychological assessments for three core EFs. The COMT polymorphism was genotyped using the TaqMan SNP Genotyping Assay. Participants were divided into three study groups: Val homozygotes, heterozygotes, and Met homozygotes. The three COMT genotype groups had significantly different performances in set-shifting [χ2 (2, 54) = 9.717, p = 0.008] and working memory tasks [χ2 (2, 54) = 7.806, p = 0.020]. Post-hoc analyses revealed that PD Val homozygotes performed significantly poorer in the set-shifting task than did either the PD Met homozygotes (z = -2.628, p = 0.009) or PD heterozygotes (z = -2.212, p = 0.027). Our explorative results suggest that the putative level of prefrontal dopamine influenced set-shifting through a "cane-shaped" dopamine level-response relationship. Our results have clinical implications, which may influence PD treatment with dopamine in the future because the optimal dopamine level to maximize EFs may vary based on the clinical course and COMT polymorphism status. Further study recruiting a larger number of participants is needed to confirm our preliminary findings.
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