ArticleAging2019
Circulating GDF11 levels are decreased with age but are unchanged with obesity and type 2 diabetes.
Article in Aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Serum BAFF and GDF11: cross-sectional associations with glycolipid metabolism and subclinical carotid artery wall thickening in elderly type 2 diabetes patients.Frontiers in cardiovascular medicine · 2026Article
- Roles of myokines in osteoporosis under physiological and diabetic conditions.Frontiers in endocrinology · 2025Review
- Myokines: metabolic regulation in obesity and type 2 diabetes.Life metabolism · 2024Review
- A simple cell proliferation assay and the inflammatory protein content show significant differences in human plasmas from young and old subjects.Frontiers in bioengineering and biotechnology · 2024Article
- Evaluation of potential aging biomarkers in healthy individuals: telomerase, AGEs, GDF11/15, sirtuin 1, NAD+, NLRP3, DNA/RNA damage, and klotho.Biogerontology · 2023Article
- The correlation between circulating growth differentiation factor 11 and the risk of osteopenia/osteoporosis in men.Archives of osteoporosis · 2023Article
- Article
- Myostatin/Activin Receptor Ligands in Muscle and the Development Status of Attenuating Drugs.Endocrine reviews · 2022Review
- Role of circulating molecules in age-related cardiovascular and metabolic disorders.Inflammation and regeneration · 2022Review
- Metabolic Syndrome-Related Kidney Injury: A Review and Update.Frontiers in endocrinology · 2022Review
- Growth differentiation factor 11: a "rejuvenation factor" involved in regulation of age-related diseases?Aging · 2021Review
- Serum growth differentiation factor 11 is closely related to metabolic syndrome in a Chinese cohort.Journal of diabetes investigation · 2021Article
- Article
- Gdf11 gene transfer prevents high fat diet-induced obesity and improves metabolic homeostasis in obese and STZ-induced diabetic mice.Journal of translational medicine · 2019Article
- Circulating Concentrations of GDF11 are Positively Associated with TSH Levels in Humans.Journal of clinical medicine · 2019Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Growth differentiation factor 11 (GDF11) is a member of the transforming growth factor β (TGFβ) superfamily which declines with age and exerts anti-aging regenerative effects in skeletal muscle in mice. However, recent data in humans and mice are conflicting casting doubts about its true functional actions. The aim of the present study was to compare the circulating concentrations of GDF11 in individuals of different ages as well as body weight and glycemic status. Serum concentrations of GDF11 were measured by ELISA in 319 subjects. There was a significant increase in GDF11 concentrations in people in the 41-50 y group and a decline in the elder groups (61-70 and 71-80 y groups,
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.