Evidence map›Paper›PMID 30896962›Full record

ArticleAmerican journal of respiratory and critical care medicine2019

Driver Mutations in Normal Airway Epithelium Elucidate Spatiotemporal Resolution of Lung Cancer.

Humam Kadara, Smruthy Sivakumar, Yasminka Jakubek, F Anthony San Lucas, Wenhua Lang, Tina McDowell, Zachary Weber, Carmen Behrens, Gareth E Davies, Neda Kalhor and 14 more

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory and critical care medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 34 citations in OpenAlex.

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  18. Early Diagnosis and Screening for Lung Cancer.Cold Spring Harbor perspectives in medicine · 2021
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors at 5 institutions in 1 country.

Humam KadaraDepartment of Translational Molecular Pathology.
Smruthy SivakumarDepartment of Epidemiology.
Yasminka JakubekDepartment of Epidemiology.
F Anthony San LucasDepartment of Epidemiology.
Wenhua LangDepartment of Translational Molecular Pathology.
Tina McDowellDepartment of Translational Molecular Pathology.
Zachary WeberAvera Institute for Human Genetics, Sioux Falls, South Dakota.
Carmen BehrensDepartment of Thoracic/Head & Neck Medical Oncology.
Gareth E DaviesAvera Institute for Human Genetics, Sioux Falls, South Dakota.
Neda KalhorDepartment of Pathology.
Cesar MoranDepartment of Pathology.
Randa El-ZeinDepartment of Radiology, Houston Methodist Research Institute, Houston, Texas.
Reza MehranDepartment of Thoracic and Cardiovascular Surgery, and.
Stephen G SwisherDepartment of Thoracic and Cardiovascular Surgery, and.
Jing WangDepartment of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Jianjun ZhangDepartment of Thoracic/Head & Neck Medical Oncology.
Junya FujimotoDepartment of Translational Molecular Pathology.
Jerry FowlerDepartment of Epidemiology.
John V HeymachDepartment of Thoracic/Head & Neck Medical Oncology.
Steven DubinettDavid Geffen School of Medicine at University of California Los Angeles, Los Angeles, California; and.
Avrum E SpiraSection of Computational Biomedicine, School of Medicine, Boston University, Boston, Massachusetts.
Erik A EhliAvera Institute for Human Genetics, Sioux Falls, South Dakota.
Ignacio I WistubaDepartment of Translational Molecular Pathology.
Paul ScheetDepartment of Translational Molecular Pathology.
Avera Health · USThe University of Texas MD Anderson Cancer Center · USBoston University · USHouston Methodist · USUniversity of California, Los Angeles · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
UNIVERSITY OF TEXAS--SPORE IN LUNG CANCERP50CA070907 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI HEYMACH, JOHN V., MINNA, JOHN D. · 1996 to 2024
$57.4M
Statistical Methods for Population Genomics and "Next-gen" Sequencing DataR01HG005859 · NHGRI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI SCHEET, PAUL A · 2011 to 2015
$1.9M
NCI NIH HHS P30 CA016672NCI NIH HHS P50 CA070907NHGRI NIH HHS R01 HG005859
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Genes, Tumor SuppressorMutationAdenocarcinomaAdultAgedAged, 80 and overCarcinoma, Non-Small-Cell LungCell Transformation, NeoplasticEpitheliumFemaleHumansLung NeoplasmsMaleMiddle AgedSequence Analysis, DNAallelic imbalancecancerization fielddeep targeted sequencingearly-stage non–small cell lung cancernormal airway

Identifiers

PMID30896962
PMCPMC6775870
OpenAlexW2924733048

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.