Observational studyMedicine2019
Leptin mediates the relationship between fat mass and blood pressure: The Hamamatsu School-based health study.
Observational study in Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Leptin, CRP, and adiponectin correlate with body fat percentage in adolescents: systematic review and meta-analysis.Frontiers in nutrition · 2025Pooled it
- Inflammatory Biomarkers and Components of Metabolic Syndrome in Adolescents: a Systematic Review.Inflammation · 2022Pooled it
- Trial
- Childhood Obesity: A Multisystem Challenge Linking Hypertension, NAFLD, and Sleep Apnea.Medical sciences (Basel, Switzerland) · 2026Review
- Association between serum omentin-1 concentrations and body composition measured by dual-energy X-ray absorptiometry in Japanese elementary school-aged children.Journal of physiological anthropology · 2025Article
- Sex impact on daily activity and physiological, metabolic and hormonal responses to different photoperiod regimens in diet-induced obese fischer 344 rats.Journal of physiology and biochemistry · 2025Article
- Interplay between key metabolic hormones, metabolic factors, renal function, and heart rate variability in humans with obesity.Scientific reports · 2025Article
- Associations of leptin levels with psychopathology, BDNF and inflammatory cytokines in patients with chronic schizophrenia as well as gender differences.BMC psychiatry · 2025Article
- N-terminal pro-B-type natriuretic peptide levels vary by ethnicity and are associated with insulin sensitivity after gestational diabetes mellitus.Cardiovascular diabetology · 2024Article
- An experimental model of western diet in female Wistar rats leads to cardiac hypoxia related to a stimulated contractility.Journal of physiology and biochemistry · 2024Article
- Blood Pressure Correlates with Serum Leptin and Body Mass Index in Overweight Male Saudi Students.Journal of personalized medicine · 2023Article
- A Comparison Study on the Therapeutic Effect of High Protein Diets Based on Pork Protein versus Soybean Protein on Obese Mice.Foods (Basel, Switzerland) · 2022Article
- Chrono-communication and cardiometabolic health: The intrinsic relationship and therapeutic nutritional promises.Frontiers in endocrinology · 2022Review
- Pro- and anti-inflammatory adipokines are associated with cardiometabolic risk markers in Brazilian schoolchildren.European journal of pediatrics · 2021Article
- Infant weight gain and DXA-measured adolescent adiposity: data from the Japan Kids Body-composition Study.Journal of physiological anthropology · 2021Article
- The Relationship of Serum Leptin and Ghrelin Levels with Craving and Withdrawal in Opioid Use Disorder.Alpha psychiatry · 2021Article
- The relationship between body fat ratio and blood pressure in school-age children.Journal of human hypertension · 2020Article
- Maternal pre-pregnancy underweight is associated with underweight and low bone mass in school-aged children.Journal of bone and mineral metabolism · 2020Article
- Altered serum level of metabolic and endothelial factors in patients with systemic sclerosis.Archives of dermatological research · 2020Article
- The associations between some biological markers, obesity, and cardiovascular risk in Slovenian children and adolescents.BMC pediatrics · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Animal studies have shown that leptin mediates the association between obesity and hypertension. However, only a few studies have assessed this relationship in population-based epidemiological studies. This study aimed to determine whether leptin mediates the relationship between body fat and blood pressure in school-aged children.A cross-sectional survey was conducted among school-aged children in Hamamatsu, Japan. Body fat was measured using dual-energy X-ray absorptiometry. Height-normalized index of fat mass (fat mass index) was calculated by dividing fat mass by height squared. Serum leptin levels were measured by enzyme-linked immunosorbent assay. Multiple regression analysis was used to evaluate relationships between body fat, serum leptin levels, and blood pressure. The mediating effect of leptin on the association between body fat and blood pressure was assessed by causal mediation analysis and regression analysis.Both fat mass index and leptin were significantly and positively associated with blood pressure. Fat mass index was also strongly associated with serum leptin levels. Body fat and blood pressure were no longer associated after adjusting for leptin. These findings suggest that the association between body fat and blood pressure is mediated by leptin. Of the total effect of fat mass index on blood pressure, the mediating effect of leptin accounted for 78.6% (P = .03) in boys and 42.2% (P = .11) in girls.Our findings suggest that body fat is associated with blood pressure, and this association is mediated by leptin. Thus, leptin acts as a mediator that links body adiposity with blood pressure elevation in school-aged children.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.