Evidence map›Paper›PMID 30896588›Full record

ArticleSpine2019

Transport of Vancomycin and Cefepime Into Human Intervertebral Discs: Quantitative Analyses.

Qiaoqiao Zhu, Xin Gao, Mark D Brown, Frank Eismont, Weiyong Gu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Spine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Qiaoqiao ZhuDepartment of Mechanical and Aerospace Engineering, University of Miami, Coral Gables, FL.
Xin GaoDepartment of Mechanical and Aerospace Engineering, University of Miami, Coral Gables, FL.
Mark D BrownDepartment of Orthopaedics, University of Miami, Coral Gables, FL.
Frank EismontDepartment of Orthopaedics, University of Miami, Coral Gables, FL.
Weiyong GuDepartment of Mechanical and Aerospace Engineering, University of Miami, Coral Gables, FL.

Funding

Modeling of Intervertebral Disc DegenerationR21AR066240 · NIAMS · UNIVERSITY OF MIAMI CORAL GABLES · PI GU, WEIYONG · 2015 to 2016
$349k
NIAMS NIH HHS R21 AR066240
6 · The paper itself

Abstract

STUDY

designSimulation of antibiotics transport into human intervertebral disc with intravenous infusion.

objectiveThe objective of this study was to quantitatively investigate antibiotic concentrations in the disc. SUMMARY OF BACKGROUND DATA: Intravenous infusion of antibiotics is typically used to treat intervertebral disc infection in clinics. However, it is difficult to evaluate the drug concentrations within discs in vivo.

methodsA computational model was used in this study. The variation of drug charge with pH was considered in the model. Thirty-minute infusions of two commonly used antibiotics in clinic-vancomycin and cefepime-were numerically investigated. Spatial and temporal concentration distributions of these drugs in both nondegenerated and moderately degenerated discs were calculated.

resultsFor intravenous infusion of 1 g vancomycin and 2 g cefepime in 30 minutes repeated every 12 hours, it was predicted that vancomycin concentration in the disc fluctuated between 17.0 and 31.0 times of its minimum inhibitory concentration (1 ug/mL) and cefepime concentration fluctuated between 1.1 and 4.2 times of its minimum inhibitory concentration (i.e., 8 ug/mL) in about 2 days. It was also found that vancomycin concentration in moderately degenerated disc was lower than that in the nondegenerated disc.

conclusionThis study provides quantitative guidance on selecting proper dosage for treating disc infection. The method used in this study could be used to provide quantitative information on transport of other antibiotics and drugs in discs as well. LEVEL OF EVIDENCE: N/A.

Indexed as

Anti-Bacterial AgentsCefepimeHumansInfusions, IntravenousIntervertebral DiscIntervertebral Disc DegenerationModels, BiologicalVancomycinAnti-Bacterial AgentsCefepimeVancomycin

Identifiers

PMID30896588
PMCPMC6697198

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.