ArticleCognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology2019
Preferential Disruption of Auditory Word Representations in Primary Progressive Aphasia With the Neuropathology of FTLD-TDP Type A.
Article in Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Speech perception and language comprehension in primary progressive aphasia.Cortex; a journal devoted to the study of the nervous system and behavior · 2024Article
- Article
- Primary progressive aphasia: six questions in search of an answer.Journal of neurology · 2024Review
- The eyes speak when the mouth cannot: Using eye movements to interpret omissions in primary progressive aphasia.Neuropsychologia · 2023Article
- Neuropathological fingerprints of survival, atrophy and language in primary progressive aphasia.Brain : a journal of neurology · 2022Article
- FTD-PSP is an Unusual Clinical Phenotype in A Frontotemporal Dementia Patient with A Novel Progranulin Mutation.Aging and disease · 2021Article
- Modularity and granularity across the language network-A primary progressive aphasia perspective.Cortex; a journal devoted to the study of the nervous system and behavior · 2021Article
- Primary Progressive Aphasia: Toward a Pathophysiological Synthesis.Current neurology and neuroscience reports · 2021Review
- Nosology of Primary Progressive Aphasia and the Neuropathology of Language.Advances in experimental medicine and biology · 2021Article
- Taxonomic Interference Associated with Phonemic Paraphasias in Agrammatic Primary Progressive Aphasia.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Speech and Language Presentations of FTLD-TDP Type B Neuropathology.Journal of neuropathology and experimental neurology · 2020Article
- Non-fluent/Agrammatic Variant of Primary Progressive Aphasia With Generalized Auditory Agnosia.Frontiers in neurology · 2020Article
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Authors and funding
9 authors.
Funding
Abstract
Four patients with primary progressive aphasia displayed a greater deficit in understanding words they heard than words they read, and a further deficiency in naming objects orally rather than in writing. All four had frontotemporal lobar degeneration-transactive response DNA binding protein Type A neuropathology, three determined postmortem and one surmised on the basis of granulin gene (GRN) mutation. These features of language impairment are not characteristic of any currently recognized primary progressive aphasia variant. They can be operationalized as manifestations of dysfunction centered on a putative auditory word-form area located in the superior temporal gyrus of the left hemisphere. The small size of our sample makes the conclusions related to underlying pathology and auditory word-form area dysfunction tentative. Nonetheless, a deeper assessment of such patients may clarify the nature of pathways that link modality-specific word-form information to the associations that mediate their recognition as concepts. From a practical point of view, the identification of these features in patients with primary progressive aphasia should help in the design of therapeutic interventions where written communication modalities are promoted to circumvent some of the oral communication deficits.
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