ArticleeLife2019
A calcium transport mechanism for atrial fibrillation in Tbx5-mutant mice.
Open access · goldAbstract read
In one paragraph
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Predictive Value of Machine Learning for Recurrence of Atrial Fibrillation after Catheter Ablation: A Systematic Review and Meta-Analysis.Reviews in cardiovascular medicine · 2023Pooled it
- A reduced TBX5-dependent gene regulatory network links atrial fibrillation and heart failure.Nature cardiovascular research · 2026Article
- Reduced TBX5 dosage undermines developmental control of atrial cardiomyocyte identity in a model of human atrial disease.Development (Cambridge, England) · 2026Article
- TBX5 and CHD4 Coordinately Activate Atrial Cardiomyocyte Genes to Maintain Cardiac Rhythm Homeostasis.Circulation · 2025Article
- Cardiac FGF23 Increases Intracellular Calcium in Atrial Myocytes and the Susceptibility to Atrial Fibrillation Decreased in FGF23Journal of cellular and molecular medicine · 2025Article
- Calcium-mediated DAD in membrane potentials and triggered activity in atrial myocytes of ETV1Journal of cellular and molecular medicine · 2024Article
- The adipose-neural axis is involved in epicardial adipose tissue-related cardiac arrhythmias.Cell reports. Medicine · 2024Article
- Genetic and Molecular Underpinnings of Atrial Fibrillation.NPJ cardiovascular health · 2024Article
- Tbx5 maintains atrial identity in post-natal cardiomyocytes by regulating an atrial-specific enhancer network.Nature cardiovascular research · 2023Article
- Transcriptional Dysregulation Underlies Both Monogenic Arrhythmia Syndrome and Common Modifiers of Cardiac Repolarization.Circulation · 2023Article
- Article
- Article
- Patient-Specific TBX5-G125R Variant Induces Profound Transcriptional Deregulation and Atrial Dysfunction.Circulation · 2022Article
- Transcriptional factors in calcium mishandling and atrial fibrillation development.Pflugers Archiv : European journal of physiology · 2021Review
- Insights into the molecular basis of the palmitoylation and depalmitoylation of NCX1.Cell calcium · 2021Article
- Activation of AMP-Activated Protein Kinases Prevents Atrial Fibrillation.Journal of cardiovascular translational research · 2021Article
- Modeling Human TBX5 Haploinsufficiency Predicts Regulatory Networks for Congenital Heart Disease.Developmental cell · 2021Article
- Mechanisms underlying pro-arrhythmic abnormalities arising from Pitx2-induced electrical remodelling: an in silico intersubject variability study.Annals of translational medicine · 2021Article
- The molecular genetic basis of atrial fibrillation.Human genetics · 2020Review
- ZO-1 Regulates Intercalated Disc Composition and Atrioventricular Node Conduction.Circulation research · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 2 institutions in 1 country.
Wenli Dai *Department of Pathology, University of Chicago, Chicago, United States.ORCID 0000-0003-4328-9740
Brigitte Laforest *Departments of Pediatrics, Pathology, and Human Genetics, University of Chicago, Chicago, United States.ORCID 0000-0001-6919-8922
Leonid TyanDepartment of Pathology, University of Chicago, Chicago, United States.ORCID 0000-0001-9734-7286
Kaitlyn M ShenDepartments of Pediatrics, Pathology, and Human Genetics, University of Chicago, Chicago, United States.
Rangarajan D NadadurDepartments of Pediatrics, Pathology, and Human Genetics, University of Chicago, Chicago, United States.
Francisco J AlvaradoDepartment of Medicine, Division of Cardiovascular Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, United States.ORCID 0000-0003-0552-9029
Stefan R MazurekDepartment of Medicine, University of Chicago, Chicago, United States.
Sonja LazarevicDepartments of Pediatrics, Pathology, and Human Genetics, University of Chicago, Chicago, United States.
Margaret GadekDepartments of Pediatrics, Pathology, and Human Genetics, University of Chicago, Chicago, United States.
Yitang WangDepartment of Pathology, University of Chicago, Chicago, United States.
Ye LiDepartment of Pathology, University of Chicago, Chicago, United States.ORCID 0000-0002-2969-2894
Hector H ValdiviaDepartment of Medicine, Division of Cardiovascular Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, United States.
Le ShenDepartment of Pathology, University of Chicago, Chicago, United States.ORCID 0000-0002-4367-5476
Michael T BromanDepartment of Medicine, University of Chicago, Chicago, United States.
Ivan P MoskowitzDepartments of Pediatrics, Pathology, and Human Genetics, University of Chicago, Chicago, United States.ORCID 0000-0003-0014-4963
Christopher R WeberDepartment of Pathology, University of Chicago, Chicago, United States.ORCID 0000-0002-2117-3184
University of Chicago · USUniversity of Wisconsin–Madison · US
Funding
MEDICAL SCIENTIST TRAININGT32GM007281 · NIGMS · UNIVERSITY OF CHICAGO · PI CLARK, MARCUS RAMSAY · 1985 to 2022
$32.1MMULTIDISCIPLINARY CARDIAC SCIENCEST32HL007381 · NHLBI · UNIVERSITY OF CHICAGO · PI JEANNE M DECARA, Yoav Gilad · 1985 to 2026
$12.5MRyanodine Receptors, Calcium-dependent Arrhythmias & HCMR01HL055438 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI VALDIVIA, HECTOR H · 1996 to 2023
$8.0MTARGETED ABLATION AND ALTERATION OF MOUSE PHOSPHOLAMBANR01HL026057 · NHLBI · UNIVERSITY OF CINCINNATI · PI KRANIAS, EVANGELIA G · 1985 to 2017
$5.3MGraduate Program in Biophysical Sciences at the University of Chicago - Renewal 0T32EB009412 · NIBIB · UNIVERSITY OF CHICAGO · PI ENGEL, GREGORY S, SOSNICK, TOBIN R · 2009 to 2023
$4.9MTraining Program in Developmental BiologyT32HD055164 · NICHD · UNIVERSITY OF CHICAGO · PI Sally Horne-Badovinac, Paschalis Kratsios · 2008 to 2026
$3.6MTranscriptional Control of Cardiac Conduction System Function by T-box GenesR01HL114010 · NHLBI · UNIVERSITY OF CHICAGO · PI MOSKOWITZ, IVAN PAUL, NOBREGA, MARCELO A. · 2012 to 2016
$2.6MGene Regulatory Networks for Cardiac MorphogenesisR01HL126509 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CONLON, FRANK LEO, CRISTEA, ILEANA M. · 2017 to 2020
$2.5MNatural Agonists of Ryanodine Receptors: Structure-function Relationship and Antiarrhythmic PropertiesR01HL134344 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI VALDIVIA, HECTOR H · 2017 to 2020
$1.9MFunctional Assays to Screen Genomic HitsR33HL123857 · NHLBI · UNIVERSITY OF CHICAGO · PI MOSKOWITZ, IVAN PAUL, NOBREGA, MARCELO A. · 2016 to 2018
$1.5MCalcins as Membrane-permeable Ligands of Ryanodine ReceptorsR01HL108175 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI VALDIVIA, HECTOR H · 2011 to 2014
$1.4MTARGETED ABLATION AND ALTERATION OF PHOSPHOLAMBANR37HL026057 · NHLBI · UNIVERSITY OF CINCINNATI · PI KRANIAS, EVANGELIA G · 1994 to 2003
$1.1MAmerican Heart Association Collaborative Sciences AwardNHLBI NIH HHS R01 HL026057NHLBI NIH HHS R01 HL055438NHLBI NIH HHS R01 HL108175NHLBI NIH HHS R01 HL114010NHLBI NIH HHS R01 HL126509NHLBI NIH HHS R01 HL134344NHLBI NIH HHS R33 HL123857NHLBI NIH HHS R37 HL026057NHLBI NIH HHS T32 HL007381NIBIB NIH HHS T32 EB009412NICHD NIH HHS T32 HD055164NIGMS NIH HHS T32 GM007281NIH HHS HL114010NIH HHS HL126509NIH HHS R33 HL123857NIH HHS T32GM007281NIH HHS T32HL007381
Abstract
Risk for Atrial Fibrillation (AF), the most common human arrhythmia, has a major genetic component. The T-box transcription factor TBX5 influences human AF risk, and adult-specific
Indexed as
AnimalsAtrial FibrillationCalciumCations, DivalentCells, CulturedDisease Models, AnimalMiceMutant ProteinsMyocytes, CardiacSarcoplasmic Reticulum Calcium-Transporting ATPasesT-Box Domain ProteinsAtp2a2 protein, mouseCalciumCations, DivalentMutant ProteinsSarcoplasmic Reticulum Calcium-Transporting ATPasesT-Box Domain ProteinsT-box transcription factor 5atrial fibrillationcalcium handlinghuman biologymedicinemolecular biophysicsmousesodium-calcium exchangerSR calcium ATPasestructural biologyTbx5triggered activity
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.