ArticleJournal of applied physiology (Bethesda, Md. : 1985)2019
Seven days of cold acclimation substantially reduces shivering intensity and increases nonshivering thermogenesis in adult humans.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 76 citations in OpenAlex.
- Brown Adipose Tissue: Molecular Mechanisms of Regulation, Physiological Functions, and Therapeutic Targets.MedComm · 2026Review
- Women exhibit different thermoregulatory responses to meal and cold stimuli compared to men independently of energy expenditure and body composition.European journal of nutrition · 2026Article
- Sarcolipin-SERCA uncoupling as a plausible heat source for sustaining fever.Frontiers in physiology · 2026Article
- Muscle regeneration is improved by hot water immersion but unchanged by cold following a simulated musculoskeletal injury in humans.The Journal of physiology · 2025Article
- Cold operational readiness in the military: from science to practice.BMJ military health · 2025Review
- Investigation of the relationship between BAT activity and thermal comfort under short-term cold temperature exposure.Scientific reports · 2025Article
- Impact of cold exposure on shift working seafood handlers in Northern Norway: a comparative analysis across work shifts.Journal of occupational medicine and toxicology (London, England) · 2025Article
- The Effect of 7-Day Cold Water Acclimation on Autophagic and Apoptotic Responses in Young Males.Advanced biology · 2025Article
- Effects of time-of-day on the noradrenaline, adrenaline, cortisol and blood lipidome response to an ice bath.Scientific reports · 2025Article
- Energy expenditure during physical work in cold environments: physiology and performance considerations for military service members.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Review
- The Different Shades of Thermogenic Adipose Tissue.Current obesity reports · 2024Review
- Ubiquitin ligase RNF20 coordinates sequential adipose thermogenesis with brown and beige fat-specific substrates.Nature communications · 2024Article
- A century of exercise physiology: concepts that ignited the study of human thermoregulation. Part 4: evolution, thermal adaptation and unsupported theories of thermoregulation.European journal of applied physiology · 2024Review
- Weighing in on the role of brown adipose tissue for treatment of obesity.Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques · 2024Review
- To the extreme! How biological anthropology can inform exercise physiology in extreme environments.Comparative biochemistry and physiology. Part A, Molecular & integrative physiology · 2023Review
- Determination of the Effects of a Series of Ten Whole-Body Cryostimulation Sessions on Physiological Responses to Exercise and Skin Temperature Behavior following Exercise in Elite Athletes.Journal of clinical medicine · 2023Article
- Thermal dysregulation in patients with multiple sclerosis during SARS-CoV-2 infection. The potential therapeutic role of exercise.Multiple sclerosis and related disorders · 2022Review
- Influences of ovarian hormones on physiological responses to cold in women.Temperature (Austin, Tex.) · 2022Review
- Human cold habituation: Physiology, timeline, and modifiers.Temperature (Austin, Tex.) · 2022Review
- Human vulnerability and variability in the cold: Establishing individual risks for cold weather injuries.Temperature (Austin, Tex.) · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Daily compensable cold exposure in humans reduces shivering by ~20% without changing total heat production, partly by increasing brown adipose tissue thermogenic capacity and activity. Although acclimation and acclimatization studies have long suggested that daily reductions in core temperature are essential to elicit significant metabolic changes in response to repeated cold exposure, this has never directly been demonstrated. The aim of the present study is to determine whether daily cold-water immersion, resulting in a significant fall in core temperature, can further reduce shivering intensity during mild acute cold exposure. Seven men underwent 1 h of daily cold-water immersion (14°C) for seven consecutive days. Immediately before and following the acclimation protocol, participants underwent a mild cold exposure using a novel skin temperature clamping cold exposure protocol to elicit the same thermogenic rate between trials. Metabolic heat production, shivering intensity, muscle recruitment pattern, and thermal sensation were measured throughout these experimental sessions. Uncompensable cold acclimation reduced total shivering intensity by 36% (
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.