ArticleStroke2019
Risk Factors for Stroke in Patients With Sepsis and Bloodstream Infections.
Article in Stroke, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 5 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Sepsis as an independent risk factor in atrial fibrillation and cardioembolic stroke.Frontiers in endocrinology · 2023Pooled it
- Neurological and Head/Eyes/Ears/Nose/Throat Manifestations of COVID-19: A Systematic Review and Meta-Analysis.The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques · 2022Pooled it
- Long-term risk and predictors of cerebrovascular events following sepsis hospitalization: A systematic review and meta-analysis.Frontiers in medicine · 2022Pooled it
- Risk of stroke in hospitalized SARS-CoV-2 infected patients: A multinational study.EBioMedicine · 2020Pooled it
- A comparison of different antibiotic regimens for the treatment of infective endocarditis.The Cochrane database of systematic reviews · 2020Pooled it
- Platelet homeostasis and heterogeneity in inflammation and sepsis: mechanisms, biological effects, and clinical potential.Cell communication and signaling : CCS · 2026Review
- Sepsis in multimorbidity: a domain-based framework for systemic vulnerability and precision care.Frontiers in medicine · 2026Review
- Construction of a Risk Prediction Model for Stroke Occurrence in Septic Shock Patients: A Combined Analysis Using LASSO and Multivariate Logistic Regression.International journal of general medicine · 2026Article
- Factors Associated With Mortality Among Adult Hemorrhagic Stroke Patients in Public Hospitals in the Harari Region, Eastern Ethiopia: A Retrospective Hospital-Based Cohort Study.Stroke research and treatment · 2026Article
- Early systemic heparin exposure is associated with lower mortality, reduced disseminated intravascular coagulation, and fewer thrombotic complications in septic shock.Frontiers in medicine · 2026Article
- Anti-KLHL11 antibody encephalitis without detectable malignancy: a case report and literature review.Frontiers in immunology · 2026Review
- Molecular profiling of brain endothelial cell to astrocyte endfoot communication in mouse and human.Nature communications · 2025Article
- Long-term cardiovascular outcomes and risk factors in adult sepsis survivors: a systematic review and meta-analysis.World journal of emergency medicine · 2025Review
- Machine learning model to predict sepsis in ICU patients with intracerebral hemorrhage.Scientific reports · 2025Article
- Septic cerebral embolism following lumbar spine surgery in a 69-year-old man with a lumbar epidural abscess in Korea: a case report.Ewha medical journal · 2024Article
- [Inflammatory causes of stroke-Diagnostics and treatment].Der Nervenarzt · 2024Article
- Predicting stroke risk after sepsis hospitalization with new-onset atrial fibrillation.Journal of hospital medicine · 2024Article
- Prevalence, predictors, and outcomes of acute respiratory distress syndrome in severe stroke.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Association between delayed invasive blood pressure monitoring and all-cause mortality in intensive care unit patients with sepsis: a retrospective cohort study.Frontiers in medicine · 2024Article
- Association between ischemic stroke and pyogenic spondylitis in Korea: Nationwide longitudinal cohort study.Journal of cerebrovascular and endovascular neurosurgery · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Background and Purpose- Sepsis has been identified as a trigger for stroke, but the underlying mechanisms and risk factors that predispose patients with sepsis to increased stroke risk remain unclear. We sought to identify predictors of stroke after sepsis and bloodstream infections. Methods- The 2007-2009 California State Inpatient Database from the Health Care Utilization Project was used to identify patients over the age of 18 years and hospitalized with sepsis or bloodstream infection defined by International Classification of Diseases, Ninth Revision codes. Patients who died during their sepsis hospitalization were excluded. The primary outcome was a primary diagnosis of ischemic or hemorrhagic stroke on a subsequent hospitalization within 1 year. Associations between risk factors, also defined by International Classification of Diseases, Ninth Revision codes, and stroke were analyzed using multivariable logistic regression. A composite risk score was generated to predict stroke risk. Results- Of 121 947 patients with sepsis, 0.5% (n=613) had a primary diagnosis of stroke within a year of their sepsis hospitalization. Significant predictors for stroke were identified. A score was generated from these risk factors with points assigned based on regression coefficients: valvular heart diseases (1 point), congestive heart failure (1), renal failure (1), lymphoma (2), peripheral vascular diseases (2), pulmonary circulation disorders (2), and coagulopathy (3). The C statistic for the receiver operating characteristic curve for the score was 0.68. The risk of stroke increased 43% (odds ratio, 1.43; 95% CI, 1.37-1.48) per-point increase in the score. The effect of increase in score was greater among younger patients. Conclusions- Risk factors and a composite risk score for stroke may help identify a subpopulation of sepsis patients that could be targeted to reduce the short-term risk of stroke after serious infections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.