ArticleNeuropsychology2019
Cognitive dispersion is a sensitive marker for early neurodegenerative changes and functional decline in nondemented older adults.
Article in Neuropsychology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 2 of them syntheses that pooled it.
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The trial behind it
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Who cites it
49 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Associations of cognitive intraindividual variability with Alzheimer's disease risk: A systematic review.The Clinical neuropsychologist · 2026Pooled it
- Cognitive Intra-individual Variability in Cognitively Healthy APOE ε4 Carriers, Mild Cognitive Impairment, and Alzheimer's Disease: a Meta-analysis.Neuropsychology review · 2025Pooled it
- Can Individualized-Targeted Computerized Cognitive Training Benefit Adults with HIV-Associated Neurocognitive Disorder? The Training on Purpose Study (TOPS).AIDS and behavior · 2021Trial
- Reliability and stability of cognitive intraindividual variability indices among cognitively unimpaired older adults.The Clinical neuropsychologist · 2026Article
- Cognitive dispersion is associated with white matter hyperintensities in amyloid positive older adults.The Clinical neuropsychologist · 2026Article
- Cognitive and Neuroimaging Biomarker Intra-Individual Variability in Alzheimer's Disease.medRxiv : the preprint server for health sciences · 2026Article
- Intraindividual cognitive variability predicts amyloid beta, tau PET, and dementia conversion in Down syndrome: a potential marker of cognitive resilience.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Global and domain-specific cognitive intraindividual variability associations with neurodegenerative diagnoses and postmortem pathologies.Alzheimer's research & therapy · 2026Article
- Cognitive dispersion in established adulthood: etiology and implications for cognitive aging.Innovation in aging · 2026Article
- Dispersion-based cognitive intra-individual variability in former American football players: Association with traumatic encephalopathy syndrome, repetitive head impacts, and biomarkers.The Clinical neuropsychologist · 2025Article
- Cognitive variation reflects amyloid, tau, and neurodegenerative biomarkers in Alzheimer's disease.GeroScience · 2025Article
- Characterizing Cognitive Dispersion and Its Correlates Across the Adult Lifespan in MIDUS.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- Interactive effects of post-traumatic stress disorder symptom severity and hypertension on cognitive dispersion in older Vietnam-Era veterans with history of post-traumatic stress disorder.Journal of the International Neuropsychological Society : JINS · 2025Article
- Growth-associated protein 43 is associated with faster functional decline among amyloid-positive individuals with objectively defined subtle cognitive decline and mild cognitive impairment.Neuropsychology · 2025Article
- Examining the Stability and Predictive Utility of Across- and Within-Domain Intra-Individual Variability in Mild Cognitive Impairment.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2025Article
- Brain connectivity moderated the effects of cognitive intraindividual variability on mobility in cognitively frail older adults.Frontiers in aging neuroscience · 2025Article
- Adherence timescale impacts completion rates of high-frequency mobile cognitive assessments among older adults.Exploration of medicine · 2025Article
- Exploring the relationship between mean performance and within-person variability on smartphone-based cognitive testing in adults across the lifespan.NPP - digital psychiatry and neuroscience · 2025Article
- A Brief Report of an Executive Functioning Training Pilot RCT in Adults with HIV: A Descriptive Case Comparison Study.Nursing (Auckland, N.Z.) · 2025Article
- Does cognitive intra-individual variability predict change in everyday functioning performance in women with and without HIV in the Women's Interagency HIV Study?Applied neuropsychology. Adult · 2024Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
objectiveIntraindividual cognitive variability (IIV), a measure of within-person variability across cognitive measures at a single time point, is associated with mild cognitive impairment (MCI) and Alzheimer's disease (AD). Little is known regarding brain changes underlying IIV, or the relationship between IIV and functional ability. Therefore, we investigated the association between IIV and cerebral atrophy in AD-vulnerable regions and everyday functioning in nondemented older adults.
method736 Alzheimer's Disease Neuroimaging Initiative (ADNI) participants (285 cognitively normal [CN]; 451 MCI) underwent neuropsychological testing and serial MRI over 2 years. Linear mixed effects models examined the association between baseline IIV and change in entorhinal cortex thickness, hippocampal volume, and everyday functioning.
resultsAdjusting for age, sex, apolipoprotein E genotype, amyloid-β positivity, and mean level of cognitive performance, higher baseline IIV predicted faster rates of entorhinal and hippocampal atrophy, as well as functional decline. Higher IIV was associated with both entorhinal and hippocampal atrophy among MCI participants but selective vulnerability of the entorhinal cortex among CN individuals.
conclusionsIIV was associated with more widespread medial temporal lobe (MTL) atrophy in individuals with MCI relative to CN, suggesting that IIV may be tracking advancing MTL pathologic changes across the continuum of aging, MCI, and dementia. Findings suggest that cognitive dispersion may be a sensitive marker of neurodegeneration and functional decline in nondemented older adults. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
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