Evidence map›Paper›PMID 30895924›Full record

ArticleeLife2019

Accelerating cancer without mutations.

Douglas E Brash

Abstract readComment
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

Douglas E BrashDepartment of Therapeutic Radiology, Yale School of Medicine, New Haven, United States.ORCID 0000-0001-7437-9373

Funding

Applying Genomic Dosimeters of UV Damage to Predicting Skin Cancer RiskR01ES030562 · NIEHS · YALE UNIVERSITY · PI BRASH, DOUGLAS E · 2019 to 2024
$2.6M
Using Clonal and Non-Clonal UV Signature Mutations to Predict Skin Cancer RiskR01CA240602 · NCI · YALE UNIVERSITY · PI BRASH, DOUGLAS E · 2019 to 2023
$2.5M
Chemiexcitation: A New Mode of Skin DiseaseR01AR070851 · NIAMS · YALE UNIVERSITY · PI BRASH, DOUGLAS E · 2017 to 2020
$1.7M
NCI NIH HHS R01 CA240602NIAMS NIH HHS R01 AR070851NIEHS NIH HHS R01 ES030562
6 · The paper itself

Abstract

Mice get melanoma faster when they have common, inherited variants in a few genes that control cell-wide changes but also respond to the environment.

Indexed as

MelanomaSkin NeoplasmsAnimalsMiceMutationUltraviolet Rayscancercancer biologymelanomamodifier genesmouseribosomesRNA-binding proteinultraviolet radiation

Identifiers

PMID30895924
PMCPMC6428566

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.