Evidence map›Paper›PMID 30895749›Full record

ArticleBrain and behavior2019

The potential role of auditory prediction error in decompensated tinnitus: An auditory mismatch negativity study.

Mehrnaz Mohebbi, Ahmad Daneshi, Abdoreza Asadpour, Samer Mohsen, Mohammad Farhadi, Saeid Mahmoudian

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain and behavior, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.9field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 29 citations in OpenAlex.

  1. What Do Mismatch Negativity (MMN) Responses Tell Us About Tinnitus?Journal of the Association for Research in Otolaryngology : JARO · 2025
    Review
  2. Article
  3. Review
  4. Clinical and investigational tools for monitoring noise-induced hyperacusis.The Journal of the Acoustical Society of America · 2022
    Review
  5. Article
  6. Too Blind to See the Elephant? Why Neuroscientists Ought to Be Interested in Tinnitus.Journal of the Association for Research in Otolaryngology : JARO · 2021
    Review
  7. Article
  8. Exposing Pathological Sensory Predictions in Tinnitus Using Auditory Intensity Deviant Evoked Responses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Mehrnaz MohebbiENT and Head & Neck Research Center and Department, The Five Senses Institute, Hazrat Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
Ahmad DaneshiENT and Head & Neck Research Center and Department, The Five Senses Institute, Hazrat Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
Abdoreza AsadpourDepartment of Electrical Engineering, Sharif University of Technology, Tehran, Iran.
Samer MohsenDepartment of Otolaryngology, Faculty of Medicine, Damascus University, Damascus, Syria.
Mohammad FarhadiENT and Head & Neck Research Center and Department, The Five Senses Institute, Hazrat Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
Saeid MahmoudianENT and Head & Neck Research Center and Department, The Five Senses Institute, Hazrat Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
Iran University of Medical Sciences · IRDamascus University · SYMedizinische Hochschule Hannover · DESharif University of Technology · IR

Funding

Iran Ministry of health 271/7.11.2016
6 · The paper itself

Abstract

introductionSome tinnitus subjects habituate to their tinnitus but some others do not and complain of its annoyance tremendously. Normal sensory memory and change detection processes are needed for detecting the tinnitus signal as a prediction error and habituation to tinnitus. The purpose of this study was to compare auditory mismatch negativity as the index of sensory memory and change detection among the studied groups to search for the factors involving in the perception of tinnitus and preventing habituation in decompensated tinnitus subjects.

methodsElectroencephalography was recorded from scalp electrodes in compensated tinnitus, decompensated tinnitus, and no tinnitus control subjects. Mismatch negativity was obtained using the oddball paradigm with frequency, duration, and silent gap deviants. Amplitude, latency, and area under the curve of mismatch negativities were compared among the three studied groups.

resultsThe results showed lower mismatch negativity amplitude and area under the curve for the higher frequency deviant and for the silent gap deviant in decompensated tinnitus group compared to normal control and compensated tinnitus group.

conclusionsThis study revealed a deficit in sensory memory and change detection processing in decompensated tinnitus subjects. This causes persistent prediction errors; tinnitus signal is consistently detected as a new signal and activates the brain salience network and consequently prevents habituation to tinnitus. Mismatch negativity is proposed as an index for monitoring tinnitus rehabilitation.

Indexed as

Acoustic StimulationAdultAudiometry, Pure-ToneAuditory PerceptionBrainElectroencephalographyEvoked Potentials, AuditoryFemaleHumansMaleMemoryTinnituschange detectionhabituationmismatch negativityprediction errorsensory memorytinnitus

Identifiers

PMID30895749
PMCPMC6456780
OpenAlexW2922869592

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.