Evidence map›Paper›PMID 30895748›Full record

ArticleMolecular genetics & genomic medicine2019

Influence of IL-1R2 polymorphisms on endometrial cancer susceptibility in the Chinese Han population.

Jiamin Wu, Wenjie Zhang, Junhong Cai, Sizhe Huang, Fanglin Niu, Ying Zhang, Shan Bao, Tianbo Jin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular genetics & genomic medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Jiamin WuKey Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University, Xi'an, Shaanxi, China.
Wenjie ZhangDepartment of Women's Health Care, Northwest Women and Children Hospital, Xi'an, Shaanxi, China.
Junhong CaiKey Laboratory of Cell and Molecular Genetic Translational Medicine in Hainan Province, Hainan General Hospital, Haikou, Hainan, China.
Sizhe HuangDepartment of Gynaecology and Obstetrics, Hainan General Hospital, Haikou, Hainan, China.
Fanglin NiuKey Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University, Xi'an, Shaanxi, China.
Ying ZhangKey Laboratory of Cell and Molecular Genetic Translational Medicine in Hainan Province, Hainan General Hospital, Haikou, Hainan, China.
Shan BaoDepartment of Gynaecology and Obstetrics, Hainan General Hospital, Haikou, Hainan, China.ORCID 0000-0003-2139-0151
Tianbo JinKey Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University, Xi'an, Shaanxi, China.
Hainan General Hospital · CNMinistry of Education of the People's Republic of China · CNNorthwest Women's and Children's Hospital · CN

Funding

Ministry of Education ZSK2017004Northwest UniversityOpening Foundation of Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education ZSK2017004Western
6 · The paper itself

Abstract

backgroundRecently, many studies have identified that genetic factor plays a crucial role in endometrial cancer development. The purpose of this study is to investigate the influence of single nucleotide polymorphisms (SNPs) of IL-1R2 on endometrial cancer susceptibility.

methodsWe performed a case-control study that included 293 patients with endometrial cancer and 579 healthy controls. Six SNPs in the IL-1R2 gene were genotyped using the Agena MassARRAY platform. Genetic models and haplotype analyses were used to assess the association between SNPs and endometrial cancer risk by computing odds ratios (ORs) and 95% confidence intervals (CIs).

resultsOverall analysis results found that two SNPs (rs4851527 and rs3218896) and haplotypes TGTC and TACT were significantly associated with endometrial cancer risk. Stratified analysis by age showed that rs2072472 was associated with endometrial cancer risk in age >54 subgroup.

conclusionsThese findings suggested that IL-1R2 polymorphisms may contribute to the development of endometrial cancer. Further studies are required to confirm the results.

Indexed as

Polymorphism, Single NucleotideAgedChinaEndometrial NeoplasmsFemaleHaplotypesHumansMiddle AgedReceptors, Interleukin-1 Type IIIL1R2 protein, humanReceptors, Interleukin-1 Type IIendometrial cancerIL-1R2polymorphismssusceptibility

Identifiers

PMID30895748
PMCPMC6503006
OpenAlexW2924639245

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.