Evidence map›Paper›PMID 30895747›Full record

ArticleMolecular genetics & genomic medicine2019

Association between IL-1R2 polymorphisms and lung cancer risk in the Chinese Han population: A case-control study.

Chaoying Wang, Chengsheng Zhang, Junnv Xu, Yongfu Li, Jie Wang, Hui Liu, Yueli Liu, Zhong Chen, Haifeng Lin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular genetics & genomic medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Chaoying WangDepartment of Medical Oncology, The Second Affiliated Hospital of Hainan Medical University, Haikou, China.
Chengsheng ZhangDepartment of Medical Oncology, The Second Affiliated Hospital of Hainan Medical University, Haikou, China.
Junnv XuDepartment of Medical Oncology, The Second Affiliated Hospital of Hainan Medical University, Haikou, China.
Yongfu LiDepartment of Medical Oncology, The Second Affiliated Hospital of Hainan Medical University, Haikou, China.
Jie WangDepartment of Nursing, The Second Affiliated Hospital of Hainan Medical University, Haikou, China.
Hui LiuDepartment of Anatomy, Hainan Medical University, Haikou, China.
Yueli LiuDepartment of Pharmacology, Hainan Medical University, Haikou, China.
Zhong ChenHainan Provincial Third People's Hospital, Sanya, China.
Haifeng LinDepartment of Medical Oncology, The Second Affiliated Hospital of Hainan Medical University, Haikou, China.ORCID 0000-0002-2181-4439
Hainan Medical University · CNSanya Central Hospital · CN

Funding

Technology Key Project of Hainan Provincial Department of Science and Technology No.ZDYF2017133
6 · The paper itself

Abstract

backgroundInterleukin-1 receptor 2 (IL-1R2), as an anti-inflammatory cytokine, is involved in the pathogenesis and progression of lung cancer. However, the role of IL-1R2 polymorphisms in patients with lung cancer has yet to be fully elucidated.

methodsSix single-nucleotide polymorphisms (SNPs) in IL-1R2 were genotyped in 259 patients and 346 healthy controls. We used the chi-squared test, genetic model analysis, Haploview analysis, and multifactor dimensionality reduction (MDR) to evaluate the potential association between IL-1R2 polymorphisms and lung cancer susceptibility. Bioinformatics analyses were conducted to analyze the expression level of IL-1R2 and its association with the overall survival of lung cancer.

resultsOur results found that rs3218977-GG was associated with a decreased risk of lung cancer (odds ratio [OR] = 0.39; 95% confidence interval [CI]: 0.17-0.87; p = 0.023), and rs2072472 had a significant risk-increasing effect in the dominant model (AG + GG vs. AA: OR = 1.54; 95% CI: 1.09-2.20; p = 0.015). The MDR model also revealed that rs2072472 is the most influential risk factor of lung cancer (testing accuracy = 0.543; cross-validation consistency = 10/10; p = 0.032). In addition, our results indicated that the IL-1R2 mRNA level was downregulated in lung cancer patients, whereas the high expression of IL-1R2 was related to a poor prognosis in lung cancer.

conclusionsOur results suggest that genetic variants of IL-1R2 may play a role in lung cancer susceptibility. Further population and functional validations of our findings are warranted.

Indexed as

Polymorphism, Single NucleotideAgedChinaFemaleHumansLung NeoplasmsMaleMiddle AgedReceptors, Interleukin-1 Type IIIL1R2 protein, humanReceptors, Interleukin-1 Type IICase-control studyIL-1R2 geneLung cancerSingle-nucleotide polymorphism

Identifiers

PMID30895747
PMCPMC6503014
OpenAlexW2924341319

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.