Evidence map›Paper›PMID 30895699›Full record

ArticleEnvironmental microbiology2019

Syntrophus aciditrophicus uses the same enzymes in a reversible manner to degrade and synthesize aromatic and alicyclic acids.

Kimberly L James, Johannes W Kung, Bryan R Crable, Housna Mouttaki, Jessica R Sieber, Hong H Nguyen, Yanan Yang, Yongming Xie, Jonathan Erde, Neil Q Wofford and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Elevated COToxics · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. The missing enzymatic link in syntrophic methane formation from fatty acids.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Kimberly L JamesDepartment of Microbiology and Plant Biology, University of Oklahoma, Norman, OK, 73019, USA.
Johannes W KungDepartment of Microbiology and Plant Biology, University of Oklahoma, Norman, OK, 73019, USA.
Bryan R CrableDepartment of Microbiology and Plant Biology, University of Oklahoma, Norman, OK, 73019, USA.
Housna MouttakiDepartment of Microbiology and Plant Biology, University of Oklahoma, Norman, OK, 73019, USA.
Jessica R SieberDepartment of Microbiology and Plant Biology, University of Oklahoma, Norman, OK, 73019, USA.
Hong H NguyenDepartment of Chemistry & Biochemistry, University of California, Los Angeles, CA, 90095, USA.
Yanan YangDepartment of Chemistry & Biochemistry, University of California, Los Angeles, CA, 90095, USA.
Yongming XieDepartment of Chemistry & Biochemistry, University of California, Los Angeles, CA, 90095, USA.
Jonathan ErdeDepartment of Chemistry & Biochemistry, University of California, Los Angeles, CA, 90095, USA.
Neil Q WoffordDepartment of Microbiology and Plant Biology, University of Oklahoma, Norman, OK, 73019, USA.
Elizabeth A KarrDepartment of Microbiology and Plant Biology, University of Oklahoma, Norman, OK, 73019, USA.
Joseph A LooUCLA DOE Institute, University of California, Los Angeles, CA, 90095, USA.
Rachel R Ogorzalek LooUCLA DOE Institute, University of California, Los Angeles, CA, 90095, USA.
Robert P GunsalusDepartment of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA, USA.
Michael J McInerneyDepartment of Microbiology and Plant Biology, University of Oklahoma, Norman, OK, 73019, USA.
University of Oklahoma · USUniversity of California, Los Angeles · US

Funding

Impact of Non-canonical Decoding on the ProteomeR01GM085402 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LOO, JOSEPH A, OGORZALEK LOO, RACHEL R. · 2008 to 2011
$1.2M
Mass Spectrometry Imaging of Protein GelsR01GM104610 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LOO, JOSEPH A, OGORZALEK LOO, RACHEL R. · 2012 to 2015
$1.2M
Department of Energy DE-FG02-96ER20214Department of Energy Office of Science (BER) DE-FC-02-02ER63421NIGMS NIH HHS R01 GM085402NIGMS NIH HHS R01 GM104610NIH HHS R01GM085402NIH HHS R01GM104610Office of Basic Energy SciencesUCLA-DOE Institute
6 · The paper itself

Abstract

Syntrophy is essential for the efficient conversion of organic carbon to methane in natural and constructed environments, but little is known about the enzymes involved in syntrophic carbon and electron flow. Syntrophus aciditrophicus strain SB syntrophically degrades benzoate and cyclohexane-1-carboxylate and catalyses the novel synthesis of benzoate and cyclohexane-1-carboxylate from crotonate. We used proteomic, biochemical and metabolomic approaches to determine what enzymes are used for fatty, aromatic and alicyclic acid degradation versus for benzoate and cyclohexane-1-carboxylate synthesis. Enzymes involved in the metabolism of cyclohex-1,5-diene carboxyl-CoA to acetyl-CoA were in high abundance in S. aciditrophicus cells grown in pure culture on crotonate and in coculture with Methanospirillum hungatei on crotonate, benzoate or cyclohexane-1-carboxylate. Incorporation of

Indexed as

AcetatesAcetyl Coenzyme AAcidsAcyl Coenzyme ABacterial ProteinsBenzoatesCyclohexanecarboxylic AcidsDeltaproteobacteriaElectron TransportMethaneMethanospirillumProteomicsAcetatesAcetyl Coenzyme AAcidsAcyl Coenzyme ABacterial ProteinsBenzoatesCyclohexanecarboxylic AcidsMethane

Identifiers

PMID30895699
PMCPMC6488403
OpenAlexW2923917957

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.