ReviewJournal of biomedical materials research. Part B, Applied biomaterials2019
Threats to adhesive/dentin interfacial integrity and next generation bio-enabled multifunctional adhesives.
Review in Journal of biomedical materials research. Part B, Applied biomaterials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Effect of ammonia-free silver fluoride application on the resin-dentin interface subjected to an in situ cariogenic challenge.Clinical oral investigations · 2026Article
- Physico-Chemical Properties and Performance of Functional Monomers Used in Contemporary Dental Adhesive Technology.The journal of adhesive dentistry · 2025Review
- Evolution of Dental Resin Adhesives-A Comprehensive Review.Journal of functional biomaterials · 2025Review
- Synergistic effects of bacteria, enzymes, and cyclic mechanical stresses on the bond strength of composite restorations.Biomaterials advances · 2025Article
- Engineered Peptides Enable Biomimetic Route for Collagen Intrafibrillar Mineralization.International journal of molecular sciences · 2023Article
- Peptides in Dentistry: A Scoping Review.Bioengineering (Basel, Switzerland) · 2023Article
- In Search of Novel Degradation-Resistant Monomers for Adhesive Dentistry: A Systematic Review and Meta-Analysis.Biomedicines · 2022Review
- Article
- Physicochemical and biological properties of experimental dental adhesives doped with a guanidine-based polymer: an in vitro study.Clinical oral investigations · 2022Article
- Peptide-Enabled Nanocomposites Offer Biomimetic Reconstruction of Silver Diamine Fluoride-Treated Dental Tissues.Polymers · 2022Article
- Synthesis, characterization and evaluation of azobenzene nanogels for their antibacterial properties in adhesive dentistry.European journal of oral sciences · 2022Article
- Commercially Available Ion-Releasing Dental Materials and Cavitated Carious Lesions: Clinical Treatment Options.Materials (Basel, Switzerland) · 2021Review
- Probing the mineralized tissue-adhesive interface for tensile nature and bond strength.Journal of the mechanical behavior of biomedical materials · 2021Article
- Reconfigurable Dual Peptide Tethered Polymer System Offers a Synergistic Solution for Next Generation Dental Adhesives.International journal of molecular sciences · 2021Article
- Chemometrics-Assisted Raman Spectroscopy Characterization of Tunable Polymer-Peptide Hybrids for Dental Tissue Repair.Frontiers in materials · 2021Article
- pH-dependent delivery of chlorhexidine from PGA grafted mesoporous silica nanoparticles at resin-dentin interface.Journal of nanobiotechnology · 2021Article
- Bioinspired multifunctional adhesive system for next generation bio-additively designed dental restorations.Journal of the mechanical behavior of biomedical materials · 2021Review
- Bibliometric Analysis of Literature Published on Antibacterial Dental Adhesive from 1996-2020.Polymers · 2020Review
- Harnessing biomolecules for bioinspired dental biomaterials.Journal of materials chemistry. B · 2020Review
- Evolution of Network Structure and Mechanical Properties in Autonomous-Strengthening Dental Adhesive.Polymers · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Nearly 100 million of the 170 million composite and amalgam restorations placed annually in the United States are replacements for failed restorations. The primary reason both composite and amalgam restorations fail is recurrent decay, for which composite restorations experience a 2.0-3.5-fold increase compared to amalgam. Recurrent decay is a pernicious problem-the standard treatment is replacement of defective composites with larger restorations that will also fail, initiating a cycle of ever-larger restorations that can lead to root canals, and eventually, to tooth loss. Unlike amalgam, composite lacks the inherent capability to seal discrepancies at the restorative material/tooth interface. The low-viscosity adhesive that bonds the composite to the tooth is intended to seal the interface, but the adhesive degrades, which can breach the composite/tooth margin. Bacteria and bacterial by-products such as acids and enzymes infiltrate the marginal gaps and the composite's inability to increase the interfacial pH facilitates cariogenic and aciduric bacterial outgrowth. Together, these characteristics encourage recurrent decay, pulpal damage, and composite failure. This review article examines key biological and physicochemical interactions involved in the failure of composite restorations and discusses innovative strategies to mitigate the negative effects of pathogens at the adhesive/dentin interface. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B:2466-2475, 2019.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.