Evidence map›Paper›PMID 30895562›Full record

SynthesisSports medicine (Auckland, N.Z.)2019

Acute Effects of Citrulline Supplementation on High-Intensity Strength and Power Performance: A Systematic Review and Meta-Analysis.

Eric T Trexler, Adam M Persky, Eric D Ryan, Todd A Schwartz, Lee Stoner, Abbie E Smith-Ryan

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Sports medicine (Auckland, N.Z.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 7 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 7 syntheses or guidelines pooled it, 68 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Eric T TrexlerHuman Movement Science Curriculum, Department of Allied Health Sciences, University of North Carolina, Chapel Hill, NC, USA.
Adam M PerskyEshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA.
Eric D RyanHuman Movement Science Curriculum, Department of Allied Health Sciences, University of North Carolina, Chapel Hill, NC, USA.
Todd A SchwartzDepartment of Biostatistics, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
Lee StonerHuman Movement Science Curriculum, Department of Allied Health Sciences, University of North Carolina, Chapel Hill, NC, USA.
Abbie E Smith-RyanHuman Movement Science Curriculum, Department of Allied Health Sciences, University of North Carolina, Chapel Hill, NC, USA. abbsmith@email.unc.edu.
University of North Carolina at Chapel Hill · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCitrulline is an increasingly common dietary supplement that is thought to enhance exercise performance by increasing nitric oxide production. In the last 5 years, several studies have investigated the effects of citrulline supplements on strength and power outcomes, with mixed results reported. To date, the current authors are unaware of any attempts to systematically review this emerging body of literature.

objectiveThe current study sought to conduct a systematic review and meta-analysis of the literature describing the effects of citrulline supplementation on strength and power outcomes.

methodsA comprehensive, systematic search of three prominent research databases was performed to find peer-reviewed, English language, original research studies evaluating the effects of citrulline supplementation on indices of high-intensity exercise performance in healthy men and women. Outcomes included strength and power variables from performance tests involving multiple repetitive muscle actions of large muscle groups, consisting of either resistance training sets or sprints lasting 30 s or less. Tests involving isolated actions of small muscle groups or isolated attempts of single-jump tasks were not included for analysis due to differences in metabolic requirements. Studies were excluded from consideration if they lacked a placebo condition for comparison, were carried out in clinical populations, provided a citrulline dose of less than 3 g, provided the citrulline dose less than 30 min prior to exercise testing, or combined the citrulline ingredient with creatine, caffeine, nitrate, or other ergogenic ingredients.

resultsTwelve studies, consisting of 13 total independent samples (n = 198 participants), met the inclusion criteria. Between-study variance, heterogeneity, and inconsistency across studies were low (Cochrane's Q = 6.9, p = 0.86; τ

conclusionThe effect size was small (0.20), and confidence intervals for each individual study crossed the line of null effect. However, the results may be relevant to high-level athletes, in which competitive outcomes are decided by small margins. Further research is encouraged to fully elucidate the effects of potential moderating study characteristics, such as the form of citrulline supplement, citrulline dose, sex, age, and strength versus power tasks.

Indexed as

Dietary SupplementsMuscle StrengthCitrullineHigh-Intensity Interval TrainingHumansPerformance-Enhancing SubstancesRandomized Controlled Trials as TopicResistance TrainingCitrullinePerformance-Enhancing Substances

Identifiers

PMID30895562
OpenAlexW2924872411

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.