Evidence map›Paper›PMID 30895533›Full record

ArticleBreast cancer research and treatment2019

Association of antidiabetic medication and statins with breast cancer incidence in women with type 2 diabetes.

Mayu Hosio, Elina Urpilainen, Mikko Marttila, Ari Hautakoski, Martti Arffman, Reijo Sund, Ulla Puistola, Esa Läärä, Arja Jukkola, Peeter Karihtala

Open access · hybridFull text readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Breast cancer research and treatment, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 3 pooled it
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 3 syntheses or guidelines pooled it, 24 citations in OpenAlex.

  1. Pooled it
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  5. Article
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  9. Metformin: A Dual-Role Player in Cancer Treatment and Prevention.International journal of molecular sciences · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Mayu HosioDepartment of Oncology and Radiotherapy, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, P.O. Box 50, 90029, Oulu, Finland.ORCID http://orcid.org/0000-0003-1194-2063
Elina UrpilainenDepartment of Obstetrics and Gynaecology, PEDEGO Research Unit, Medical Research Center Oulu, University of Oulu and University Hospital of Oulu, P.O. Box 23, 90029, Oulu, Finland.
Mikko MarttilaChildren, Adolescents and Families Unit, Department of Welfare, National Institute for Health and Welfare, P.O. Box 310, 90101, Oulu, Finland.
Ari HautakoskiResearch Unit of Mathematical Sciences, University of Oulu, P.O. Box 3000, 90014, Oulu, Finland.
Martti ArffmanService System Research Unit, National Institute for Health and Welfare, P.O. Box 30, 00271, Helsinki, Finland.
Reijo SundInstitute of Clinical Medicine, University of Eastern Finland, P.O. Box 1627, 70211, Kuopio, Finland.
Ulla PuistolaDepartment of Obstetrics and Gynaecology, PEDEGO Research Unit, Medical Research Center Oulu, University of Oulu and University Hospital of Oulu, P.O. Box 23, 90029, Oulu, Finland.
Esa LääräResearch Unit of Mathematical Sciences, University of Oulu, P.O. Box 3000, 90014, Oulu, Finland.
Arja JukkolaDepartment of Oncology and Radiotherapy, Tampere University Hospital, P.O. Box 2000, 33521, Tampere, Finland.
Peeter KarihtalaDepartment of Oncology and Radiotherapy, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, P.O. Box 50, 90029, Oulu, Finland. peeter.karihtala@oulu.fi.ORCID http://orcid.org/0000-0003-3490-3702
Oulu University Hospital · FIFinnish Institute for Health and Welfare · FIUniversity of Oulu · FITampere University Hospital · FIUniversity of Eastern Finland · FI

Funding

Jane ja Aatos Erkon Säätiö T59127Pohjois-Suomen Terveydenhuollon Tukisäätiö T59127Pohjois-Suomen Terveydenhuollon Tukisäätiö T59129
6 · The paper itself

Abstract

purposeTo address the possible association between the use of metformin, other forms of antidiabetic medication (ADM) and statins with the incidence of breast cancer in women with type 2 diabetes (T2D).

methodsData were collected from a Finnish nationwide diabetes database (FinDM). The study cohort consisted of women diagnosed with T2D in 1996-2011 in Finland. In full-cohort analysis, Poisson regression was used to estimate hazard ratios (HRs) in relation to use of metformin, insulin, other forms of oral ADM and statins. In nested case-control analysis, up to 20 controls were matched for age and duration of diabetes to each case of breast cancer. Conditional logistic regression was used to estimate HRs in relation to medication use and cumulative use of different forms of ADM, and statins.

results2300 women were diagnosed with breast cancer during follow-up. No difference in breast cancer incidence was observed between metformin users [HR 1.02, 95% confidence interval (CI) 0.93-1.11] or statin users (HR 0.97, 95% CI 0.89-1.05) compared with non-users. In nested case-control analysis the results were similar. Use of insulin (HR 1.18, 95% CI 1.03-1.36) was associated with a slightly increased incidence of breast cancer.

conclusionsNo evidence of an association between the use of metformin or statins and the incidence of breast cancer in women with T2D was found. Among insulin users, a slightly higher incidence of breast cancer was observed.

Indexed as

Administration, OralAdultAgedAged, 80 and overBreast NeoplasmsCase-Control StudiesDatabases, FactualDiabetes Mellitus, Type 2FemaleFinlandHumansHydroxymethylglutaryl-CoA Reductase InhibitorsHypoglycemic AgentsIncidenceInsulinMetforminHydroxymethylglutaryl-CoA Reductase InhibitorsHypoglycemic AgentsInsulinMetforminBreast cancerCancer incidenceCohort studyMetforminStatinsType 2 diabetes

Identifiers

PMID30895533
PMCPMC6534663
OpenAlexW2922761657

What OpenQuestion holds

Textfull text, public
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.