ArticleCalcified tissue international1986
The role of serum concentrations of sex steroids and bone turnover in the development and occurrence of postmenopausal osteoporosis.
Article in Calcified tissue international, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 130 citations in OpenAlex.
- Effect of transdermal 17 beta-estradiol and oral conjugated equine estrogens on biochemical parameters of bone resorption in natural menopause.Calcified tissue international · 1993Trial
- Article
- Association of a history of gestational diabetes mellitus with osteoporosis, bone mineral density, and trabecular bone score in postmenopausal women.Diabetology & metabolic syndrome · 2023Article
- Estrogen for the Treatment of Low Bone Mineral Density in Anorexia Nervosa.Journal of psychiatry and brain science · 2022Article
- Low serum levels of bone turnover markers are associated with perirenal fat thickness in patients with type 2 diabetes mellitus.Endocrine connections · 2021Article
- Targeting Drug Delivery in the Elderly: Are Nanoparticles an Option for Treating Osteoporosis?International journal of molecular sciences · 2021Review
- Effects of Roux-en-Y Gastric Bypass and Sleeve Gastrectomy on Bone Mineral Density in Zucker Diabetic Fatty Rats: A Short-Term Comparative Study.Obesity facts · 2021Article
- Low bone mineral density in anorexia nervosa: Treatments and challenges.Clinical reviews in bone and mineral metabolism · 2019Article
- Effects of Anorexia Nervosa on Bone Metabolism.Endocrine reviews · 2018Review
- Osteogenic potency of dedifferentiated fat cells isolated from elderly people with osteoporosis.Experimental and therapeutic medicine · 2017Article
- Obesity, Type 2 Diabetes and Bone in Adults.Calcified tissue international · 2017Review
- Article
- Anorexia nervosa and bone metabolism.Bone · 2014Review
- Bone metabolism in anorexia nervosa.Current osteoporosis reports · 2014Review
- The alliance of mesenchymal stem cells, bone, and diabetes.International journal of endocrinology · 2014Review
- Capacity of endogenous sex steroids to predict bone loss in Japanese men: 10-year follow-up of the Taiji Cohort Study.Journal of bone and mineral metabolism · 2011Article
- Influence of ferutinin on bone metabolism in ovariectomized rats. I: role in preventing osteoporosis.Journal of bone and mineral metabolism · 2009Article
- Correlation of obesity and osteoporosis: effect of fat mass on the determination of osteoporosis.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2008Review
- Skeletal effects of parathyroid hormone (1-34) in ovariectomized rats with or without concurrent administration of salmon calcitonin.AAPS pharmSci · 2001Article
- Differential patterns of osteoblast dysfunction in trabecular bone in patients with established osteoporosis.Journal of clinical pathology · 1997Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been debated whether postmenopausal osteoporosis is characterized by high or low bone turnover and whether circulating levels of sex steroids contribute to the occurrence of osteoporotic fractures. We examined 154 70-year-old women with or without osteoporotic fractures, and 178 early postmenopausal women with a "rapid" or a "slow" bone loss. In all participants, we determined markers of bone formation (serum alkaline phosphatase (AP) and serum bone Gla protein (BGP)), markers of bone resorption (fasting urinary calcium/creatinine (FU Ca/Cr) and hydroxyproline/creatinine (FU Hpr/Cr)), and serum estrone (E1), estradiol (E2), androstenedione (A), and fat mass. The 70-year-old women with osteoporotic fractures had significantly elevated AP (P less than 0.001), BGP (P less than 0.001), and FU Hpr/Cr (P less than 0.001) compared with the group without fractures. In the group of early postmenopausal women, the "rapid" bone losers had significantly increased FU Hpr/Cr (P less than 0.001) and FU Ca/Cr (P less than 0.001). E1, E2, A, and the fat mass did not differ in the groups with and without osteoporotic fractures, whereas the "rapid" bone losers had significantly lower E1 (P less than 0.05), E2 (P less than 0.05), and fat mass (P less than 0.01) than the "slow" bone losers. It is concluded that patients with manifest osteoporosis and early postmenopausal women with a rapid bone loss have increased biochemical markers of bone turnover. Moreover, the present study demonstrates that early postmenopausal women with an "excessive" bone loss have significantly decreased serum estrogens, whereas it is not possible to detect low estrogens in women with osteoporotic fractures.
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