ArticleSleep2019
Extracellular vesicles reveal abnormalities in neuronal iron metabolism in restless legs syndrome.
Article in Sleep, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Who cites it
18 citing papers in PubMed, 23 citations in OpenAlex.
- Altered iron metabolism and iron therapy in restless legs syndrome.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Serum Biomarkers in Restless Legs Syndrome: Beyond the Classical Iron Paradigm-A Scoping Review.International journal of molecular sciences · 2026Article
- Detection and Isolation of Tissue-Specific Extracellular Vesicles From the Blood.Journal of extracellular biology · 2025Review
- Extracellular vesicles: translational research and applications in neurology.Nature reviews. Neurology · 2025Review
- Molecular profiling of neuronal extracellular vesicles reveals brain tissue specific signals.Exposome · 2025Article
- Bile from the hemojuvelin-deficient mouse model of iron excess is enriched in iron and ferritin.Metallomics : integrated biometal science · 2024Article
- Brain Iron Dysregulation in Iron Deficiency Anemia-Related Restless Leg Syndrome Revealed by Neuron-Derived Extracellular Vesicles: A Case-Control Study.Annals of neurology · 2024Article
- Corrigendum: Evaluation of ferritin and TfR level in plasma neural-derived exosomes as potential markers of Parkinson's disease.Frontiers in aging neuroscience · 2023Article
- MRI findings in movement disorders and associated sleep disturbances.American journal of nuclear medicine and molecular imaging · 2023Review
- Evaluation of ferritin and TfR level in plasma neural-derived exosomes as potential markers of Parkinson's disease.Frontiers in aging neuroscience · 2023Article
- Brain-iron deficiency models of restless legs syndrome.Experimental neurology · 2022Review
- L1CAM-associated extracellular vesicles: A systematic review of nomenclature, sources, separation, and characterization.Journal of extracellular biology · 2022Article
- Exposure of metal toxicity in Alzheimer's disease: An extensive review.Frontiers in pharmacology · 2022Review
- Peripheral Iron Metabolism is Associated with Leg Movements on Polysomnography but Not with the Severity of Restless Legs Syndrome or Its Impact on Patients.Nature and science of sleep · 2022Article
- Iron and Alzheimer's Disease: From Pathology to Imaging.Frontiers in human neuroscience · 2022Review
- Synaptic and complement markers in extracellular vesicles in multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2021Article
- Circulating Exosomes of Neuronal Origin as Potential Early Biomarkers for Development of Stroke.Molecular diagnosis & therapy · 2021Review
- Mitochondrial RNA in Alzheimer's Disease Circulating Extracellular Vesicles.Frontiers in cell and developmental biology · 2020Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
STUDY
objectivesDetermine abnormalities in levels of iron-management proteins in neuronal origin-enriched extracellular vesicles (nEVs) in restless legs syndrome (RLS).
methodsWe used immunoprecipitation for neuronal marker L1CAM to isolate nEVs from the serum of 20 participants with RLS from a study including magnetic resonance imaging (MRI) determinations of iron deposition in the substantia nigra and hematologic parameters and 28 age- and sex-matched Controls.
resultsRLS compared with Control participants showed higher levels of nEV total ferritin but similar levels of transferrin receptor and ferroportin. Western blot analysis showed that heavy- but not light-chain ferritin was increased in nEVs of RLS compared with Control participants. In RLS but not Control participants, nEV total ferritin was positively correlated with systemic iron parameters; the two groups also differed in the relation of nEV total ferritin to MRI measures of iron deposition in substantia nigra.
conclusionsGiven the neuronal origin and diversity of EV cargo, nEVs provide an important platform for exploring the underlying pathophysiology and possible biomarkers of RLS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.