Evidence map›Paper›PMID 30895257›Full record

ArticleHuman reproduction open2018

The effect of endometriosis on live birth rate and other reproductive outcomes in ART cycles: a cohort study.

Charles M Muteshi, Eric O Ohuma, Tim Child, Christian M Becker

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human reproduction open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 3 pooled it
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 50 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Charles M MuteshiOxford Fertility, Institute of Reproductive Sciences, Oxford OX4 2HW, UK.ORCID 0000-0002-4980-3408
Eric O OhumaNuffield Department of Orthopaedics, Centre for Statistics in Medicine, Botnar Research Centre, Rheumatology & Musculoskeletal Sciences, University of Oxford, Oxford, UK.
Tim ChildOxford Fertility, Institute of Reproductive Sciences, Oxford OX4 2HW, UK.
Christian M BeckerNuffield Department of Women's & Reproductive Health, University of Oxford, Oxford OX3 9DU, UK.
University of Oxford · GBNuffield Orthopaedic Centre · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

study questionWhat is the effect of endometriosis compared to unexplained subfertility on live birth rate in women undergoing IVF and embryo transfer (ET)? SUMMARY ANSWER: Endometriosis decreases live birth rate in women undergoing IVF-ET treatment, particularly with increasing severity of the disease. WHAT IS KNOWN ALREADY: Endometriosis affects up to 50% of women seeking fertility treatment and is known to reduce fecundity. There remains a debate as to effects of endometriosis on the outcomes of IVF treatment, with live birth being a secondary outcome or not reported in most studies. STUDY DESIGN SIZE DURATION: A retrospective cohort study analyzing data of IVF treatment cycles from January 2000 to December 2014 was carried out. PARTICIPANTS/MATERIALS SETTING

methodsWomen with endometriosis ( MAIN RESULTS AND THE ROLE OF CHANCE: Women with endometriosis had 24% less likelihood of a live birth when compared to those with unexplained subfertility [odds ratio (OR) 0.76 (95% CI, 0.59-0.98) LIMITATIONS REASONS FOR CAUTION: The study is limited by a retrospective design. By limiting the study to a single ET cycle, it was not possible to assess the cumulative outcome including use of all frozen embryos. WIDER IMPLICATIONS OF THE

findingsEndometriosis has similar phenotypes among women in different populations and would be expected to have a similar effect on fertility. These results are therefore generalizable to other populations of women. STUDY FUNDING/COMPETING INTERESTS: None. TRIAL REGISTRATION NUMBER: Not applicable.

Indexed as

ARTembryo developmentendometriosisimplantationIVFlive birthovarian response

Identifiers

PMID30895257
PMCPMC6276688
OpenAlexW2893656416

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.