ArticleJournal of dental sciences2018
Effects of oral stimulation with capsaicin on salivary secretion and neural activities in the autonomic system and the brain.
Article in Journal of dental sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 39 citations in OpenAlex.
- Subjective Effects of Inhaling Kuromoji Tea Aroma.Molecules (Basel, Switzerland) · 2021Trial
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- Latent class analysis of oral frailty among community-dwelling older adults: functional profiles and associated factors.BMC oral health · 2026Article
- Spicy Personality: On the Relationship Between Personality Traits and the Preference for Spicy Foods.Foods (Basel, Switzerland) · 2026Review
- Association of body mass index and visceral fat with heart rate variability in university students: a BMI-stratified analysis.Frontiers in physiology · 2026Article
- Tooth Pulp Afferents and Transient Receptor Potential (TRP) Ion Channels as Key Regulators of Pulp Homeostasis, Inflammation, and Pain.International journal of molecular sciences · 2025Review
- The Role of Inflammatory Biomarkers (IL-1, IL-6, TNF-α, and Alpha-Amylase) in Saliva on Post-Odontectomy Swelling: A Rapid Review.Journal of inflammation research · 2025Review
- Article
- A scoping review of olfactory interventions for fatigue relief: addressing occupational health hazards.Frontiers in public health · 2024Article
- SARS-CoV-2 specific sIgA in saliva increases after disease-related video stimulation.Scientific reports · 2023Article
- Pungency Perception and the Interaction with Basic Taste Sensations: An Overview.Foods (Basel, Switzerland) · 2023Review
- Progress in salivary glands: Endocrine glands with immune functions.Frontiers in endocrinology · 2023Review
- Disease-related disgust promotes antibody release in human saliva.Brain, behavior, & immunity - health · 2022Article
- Effect of an Extremely Low-Frequency Electromagnetic Field on the Concentration of Salivary Immunoglobulin A.International journal of environmental research and public health · 2022Article
- Agonists of Orally Expressed TRP Channels Stimulate Salivary Secretion and Modify the Salivary Proteome.Molecular & cellular proteomics : MCP · 2020Article
- Association between salivary alpha-amylase and subjective and objective oral parafunctions in community-dwelling elderly individuals.Journal of dental sciences · 2020Article
- Endogenous salivary citrate is associated with enhanced rheological properties following oral capsaicin stimulation.Experimental physiology · 2020Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background/purposeAlthough it has been reported that capsaicin ingestion has effects of protecting stomach mucosa and promoting energy consumption, physiological responses to oral stimulation with capsaicin has not been elucidated. Therefore, we investigated the effect of oral capsaicin stimulation on oral health and mental conditions by measuring changes in salivation, autonomic nervous activity and electroencephalogram (EEG). MATERIALS AND
methodsEighteen healthy adults participated in this study. The stimulus concentrations of capsaicin and five basic taste solutions were determined based on the measured threshold of each stimulus in each subject. The weight of secreted saliva and the changes in concentrations of salivary secretory immunoglobulin A (SIgA) induced by capsaicin and taste stimuli were measured. Salivary α-amylase activity and heart rate variability (HRV) were measured as indicators of autonomic nervous activity. From EEG, psychological condition was analyzed by measuring the powers of theta, alpha, and beta bands.
resultsThe salivary secretion rate was significantly increased by stimulation with capsaicin, NaCl, and citric acid compared with deionized water, and capsaicin demonstrated the most potent effect among tested stimuli. The secreted amount of SIgA per minute was elevated by capsaicin stimulation. Salivary α-amylase activity and HRV analysis demonstrated an elevation of sympathetic nervous activity induced by capsaicin. EEG analysis showed a significant increase in beta band power.
conclusionThese results suggest that oral stimulation with capsaicin may be effective in improving oral conditions by increasing salivary flow and SIgA secretion, and in enhancing physical and mental conditions as indicated by sympathetic nerve and EEG changes.
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