ArticleJournal of dental sciences2016
Assessment of serum malondialdehyde, uric acid, and vitamins C and E levels in patients with recurrent aphthous stomatitis.
Article in Journal of dental sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Systematic review and meta-analysis of oxidative stress and antioxidant markers in recurrent aphthous stomatitis.BMC oral health · 2023Pooled it
- Role of micronutrition in patients with oral cancer and nutritional intervention strategies.Frontiers in nutrition · 2025Review
- Associations of single and multiple vitamin levels with pediatric oral mucosal diseases: a cross-sectional study with multi-model analysis.Frontiers in nutrition · 2025Article
- Relationships of interleukin-17 polymorphisms with recurrent aphthous ulcer risk in a Han Chinese population.The Journal of international medical research · 2020Article
- Serum levels of total antioxidant status, nitric oxide and nitric oxide synthase in minor recurrent aphthous stomatitis patients.Medicine · 2019Article
- Frequencies of abnormal humoral and cellular immune component levels in peripheral blood of patients with recurrent aphthous ulceration.Journal of dental sciences · 2018Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background/purposeRecurrent aphthous stomatitis (RAS) is a common oral mucosal disease. Recently, oxidative stress has been thought to play a major role in the etiopathogenesis of RAS. The aim of this investigation was to compare the serum levels of an important oxidant agent [malondialdehyde (MDA)] and nonenzymatic antioxidants [uric acid (UA) and vitamins C and E] in patients with RAS versus healthy individuals. MATERIALS AND
methodsNinety-seven patients with idiopathic minor RAS and 97 race-, age-, and sex-matched healthy individuals were included in this study. All these individuals were allocated to three groups: RAS patients in the active stage (Group A); the same RAS patients in Group A in the remission stage (Group B); and healthy individuals without RAS (Group C). The serum levels of MDA, UA, and vitamins C and E were measured by the spectrophotometric method. Independent sample
resultsSerum MDA level of Group A was significantly higher than that of Group B (P = 0.040) or Group C (P = 0.011), whereas the serum level of vitamin E was significantly decreased in Group A as compared with Group B (P = 0.012) or Group C (P = 0.001). No statistically significant differences were found between Group B and Group C in terms of MDA, UA, and vitamins C and E serum levels (P > 0.05).
conclusionWith the double-faced character of oxidant/antioxidant, UA and vitamin C may not play a crucial role in the pathogenesis of RAS. However, MDA and vitamin E can be used as indicators for RAS.
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