Evidence map›Paper›PMID 30894854›Full record

ArticleFrontiers in immunology2019

Differential Elimination of Anti-Thymocyte Globulin of Fresenius and Genzyme Impacts T-Cell Reconstitution After Hematopoietic Stem Cell Transplantation.

Lisa V E Oostenbrink, Cornelia M Jol-van der Zijde, Katrine Kielsen, Anja M Jansen-Hoogendijk, Marianne Ifversen, Klaus G Müller, Arjan C Lankester, Astrid G S van Halteren, Robbert G M Bredius, Marco W Schilham and 1 more

2 registry-linked trialsAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04936282 phase4unknown statusnot on this mapstarted 2022, after this paper: background citation

Treatment of Early Borderline Lesions in Low Immunological Risk Kidney Transplant Patients: a Spanish Multicenter, Randomized, Controlled Parallel-group Trial: The TRAINING Study

TypeinterventionalSponsorFundación Canaria Instituto de Investigación Sanitaria de CanariasRan2022 to 2024Enrolled80ConditionsKidney Transplant Failure and RejectionArmsGrafalon, Normal Treatment
NCT07635693 recruitingnot on this mapstarted 2026, after this paper: background citation

ATLG Levels and Immune Reconstitution Kinetics in Autologous HSCT for Multiple Sclerosis

TypeobservationalSponsorCiceri FabioRan2026 to 2029Enrolled20ConditionsMultiple Sclerosis, Autologous Hematopoietic Stem Cell Transplant, ATLGArmsATLG administration
3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lisa V E OostenbrinkDepartment of Pediatrics, Leiden University Medical Center, Leiden, Netherlands.
Cornelia M Jol-van der ZijdeDepartment of Pediatrics, Leiden University Medical Center, Leiden, Netherlands.
Katrine KielsenInstitute for Inflammation Research, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Anja M Jansen-HoogendijkDepartment of Pediatrics, Leiden University Medical Center, Leiden, Netherlands.
Marianne IfversenDepartment of Paediatrics and Adolescent Medicine, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Klaus G MüllerInstitute for Inflammation Research, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Arjan C LankesterDepartment of Pediatrics, Leiden University Medical Center, Leiden, Netherlands.
Astrid G S van HalterenDepartment of Pediatrics, Leiden University Medical Center, Leiden, Netherlands.
Robbert G M BrediusDepartment of Pediatrics, Leiden University Medical Center, Leiden, Netherlands.
Marco W SchilhamDepartment of Pediatrics, Leiden University Medical Center, Leiden, Netherlands.
Maarten J D van TolDepartment of Pediatrics, Leiden University Medical Center, Leiden, Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anti-thymocyte globulin (ATG) is a lymphocyte depleting agent applied in hematopoietic stem cell transplantation (HSCT) to prevent rejection and Graft-vs.-Host Disease (GvHD). In this study, we compared two rabbit ATG products, ATG-Genzyme (ATG-GENZ), and ATG-Fresenius (ATG-FRES), with respect to dosing, clearance of the active lymphocyte binding component, post-HSCT immune reconstitution and clinical outcome. Fifty-eigth pediatric acute leukemia patients (

Indexed as

AnimalsAntilymphocyte SerumGraft vs Host DiseaseHematopoietic Stem Cell TransplantationHumansLeukemia, Myeloid, AcuteLymphocyte DepletionRabbitsStem CellsT-LymphocytesTransplantation ConditioningUnrelated DonorsAntilymphocyte Serumthymoglobulinacute GvHDATGFreseniusGenzymepediatricsserotherapy

Identifiers

PMID30894854
PMCPMC6414431

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.