ReviewFrontiers in pharmacology2019
Can Positive Framing Reduce Nocebo Side Effects? Current Evidence and Recommendation for Future Research.
Review in Frontiers in pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed.
- Trial
- Positive social modeling attenuates nocebo side effects.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2025Trial
- Changing mindsets about methotrexate in the rheumatology clinic to reduce side effects and improve adherence: a randomized controlled trial.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2025Trial
- Open-label placebo treatment does not enhance cognitive abilities in healthy volunteers.Scientific reports · 2023Trial
- Presenting a sham treatment as personalised increases the placebo effect in a randomised controlled trial.eLife · 2023Trial
- Preventing adverse events of chemotherapy for gastrointestinal cancer by educating patients about the nocebo effect: a randomized-controlled trial.BMC cancer · 2022Trial
- Can positive expectations help to improve the learning of risk literacy? A cluster-randomized study in undergraduate medical students.BMC medical education · 2022Trial
- Effect of Briefing on Acupuncture Treatment Outcome Expectations, Pain, and Adverse Side Effects Among Patients With Chronic Low Back Pain: A Randomized Clinical Trial.JAMA network open · 2021Trial
- Changing mindsets about side effects.BMJ open · 2021Trial
- Trial
- Effect of written outcome information on attitude of perinatal healthcare professionals at the limit of viability: a randomized study.BMC medical ethics · 2019Trial
- The Impact of Expectations and Framing on the course of Symptom Severity in Somatic Symptom Disorder-Ecological Momentary Assessment from the SOMA.SSD Study.International journal of behavioral medicine · 2026Article
- Attitudes of caregivers of children labeled with drug allergy after delabeling by provocation tests.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026Article
- Effects of likelihood framing on side effect expectations and nocebo side effects: Results from three experimental studies with a placebo analgesic cream.British journal of health psychology · 2026Article
- [Words like medicine-Therapeutic communication in anesthesia].Die Anaesthesiologie · 2025Review
- The effect of attribute framing on beliefs and attitudes toward branded and generic medications.Journal of behavioral medicine · 2025Article
- Predicting the side effects of influenza vaccination.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2025Article
- Triadic relations in healthcare: surveying physicians' perspectives on generative AI integration and its role on empathy, the placebo effect and patient care.Frontiers in psychology · 2025Article
- Identifying the psychological effects of nocebo education: results from two pre-registered experiments.Journal of behavioral medicine · 2024Article
- Integration of ChatGPT Into a Course for Medical Students: Explorative Study on Teaching Scenarios, Students' Perception, and Applications.JMIR medical education · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although critical for informed consent, side effect warnings can contribute directly to poorer patient outcomes because they often induce negative expectations that trigger nocebo side effects. Communication strategies that reduce the development of nocebo side effects whilst maintaining informed consent are therefore of considerable interest. We reviewed theoretical and empirical evidence for the use of framing strategies to achieve this. Framing refers to the way in which information about the likelihood or significance of side effects is presented (e.g., negative frame: 30%
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.