Evidence map›Paper›PMID 30894747›Full record

ArticleNature2019

Structural basis of unidirectional export of lipopolysaccharide to the cell surface.

Tristan W Owens, Rebecca J Taylor, Karanbir S Pahil, Blake R Bertani, Natividad Ruiz, Andrew C Kruse, Daniel Kahne

Abstract read
In one paragraph

Article in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers.

0numbers the graph read from it
0cells of the map it votes in
96citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

96 citing papers in PubMed.

  1. Article
  2. The evolution of a NaJournal of bacteriology · 2026
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  4. The evolution of a NabioRxiv : the preprint server for biology · 2026
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  9. Review
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  11. Investigating the Chemical-Biological Link inFood science & nutrition · 2025
    Article
  12. Review
  13. Article
  14. The LptC transmembrane helix undergoes a rigid body movement upon LptBProtein science : a publication of the Protein Society · 2025
    Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article

36 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Tristan W OwensDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Rebecca J TaylorDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Karanbir S PahilDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Blake R BertaniDepartment of Microbiology, The Ohio State University, Columbus, OH, USA.
Natividad RuizDepartment of Microbiology, The Ohio State University, Columbus, OH, USA. ruiz.82@osu.edu.
Andrew C KruseDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA. andrew_kruse@hms.harvard.edu.
Daniel KahneDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA. kahne@chemistry.harvard.edu.

Funding

User Training and OutreachP30GM124165 · NIGMS · CORNELL UNIVERSITY · PI MALCOLM S. CAPEL · 2018 to 2026
$34.2M
Targeting bacterial cell wall biogenesis for the development of novel antimicrobU19AI109764 · NIAID · HARVARD MEDICAL SCHOOL · PI BELTZ, GERALD A · 2014 to 2018
$25.2M
Outer Membrane Biogenesis: New Antibiotic TargetsR01AI081059 · NIAID · HARVARD UNIVERSITY · PI Daniel Kahne · 2009 to 2026
$9.5M
Studies Toward Hybrid Glycopeptide AntibioticsR01GM066174 · NIGMS · PRINCETON UNIVERSITY · PI KAHNE, DANIEL · 2002 to 2018
$8.9M
Envelope Biogenesis in Gram-negative BacteriaR01GM100951 · NIGMS · OHIO STATE UNIVERSITY · PI RUIZ, NATIVIDAD · 2012 to 2023
$3.7M
Pixel Array Detector for Macromolecular CrystallographyS10OD021527 · OD · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2016 to 2016
$2.0M
NIAID NIH HHS R01 AI081059NIAID NIH HHS U19 AI109764NIGMS NIH HHS P30 GM124165NIGMS NIH HHS R01 GM066174NIGMS NIH HHS R01 GM100951NIH HHS S10 OD021527
6 · The paper itself

Abstract

Gram-negative bacteria are surrounded by an inner cytoplasmic membrane and by an outer membrane, which serves as a protective barrier to limit entry of many antibiotics. The distinctive properties of the outer membrane are due to the presence of lipopolysaccharide

Indexed as

Adenosine TriphosphateATP-Binding Cassette TransportersBacterial ProteinsBiological TransportCell MembraneCrystallography, X-RayEscherichia coliEscherichia coli ProteinsKlebsiella pneumoniaeLipopolysaccharidesMembrane ProteinsModels, MolecularMultiprotein ComplexesProtein SubunitsPseudomonas aeruginosaVibrio choleraeAdenosine TriphosphateATP-Binding Cassette TransportersBacterial ProteinsEscherichia coli ProteinsLipopolysaccharidesLptC protein, E coliLptF protein, E coliMembrane ProteinsMultiprotein ComplexesProtein Subunits

Identifiers

PMID30894747
PMCPMC6629255

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.