Evidence map›Paper›PMID 30894744›Full record

ArticleNature2019

Structural basis of lipopolysaccharide extraction by the LptB

Yanyan Li, Benjamin J Orlando, Maofu Liao

Abstract read
In one paragraph

Article in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers.

0numbers the graph read from it
0cells of the map it votes in
109citing papers in PubMed
29.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

109 citing papers in PubMed, 171 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. The LptC transmembrane helix undergoes a rigid body movement upon LptBProtein science : a publication of the Protein Society · 2025
    Article

49 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Yanyan LiDepartment of Cell Biology, Harvard Medical School, Boston, MA, USA.
Benjamin J OrlandoDepartment of Cell Biology, Harvard Medical School, Boston, MA, USA.
Maofu LiaoDepartment of Cell Biology, Harvard Medical School, Boston, MA, USA. maofu_liao@hms.harvard.edu.
Harvard University · US

Funding

Molecular Mechanisms of Lipopolysaccharide Transport Driven by ABC TransportersR01GM122797 · NIGMS · HARVARD MEDICAL SCHOOL · PI LIAO, MAOFU · 2017 to 2021
$1.7M
NIGMS NIH HHS R01 GM122797
6 · The paper itself

Abstract

In Gram-negative bacteria, lipopolysaccharide is essential for outer membrane formation and antibiotic resistance. The seven lipopolysaccharide transport (Lpt) proteins A-G move lipopolysaccharide from the inner to the outer membrane. The ATP-binding cassette transporter LptB

Indexed as

Cryoelectron MicroscopyEscherichia coliEscherichia coli ProteinsLipopolysaccharidesMembrane ProteinsModels, MolecularMultiprotein ComplexesProtein BindingProtein DomainsProtein SubunitsStructure-Activity RelationshipVanadatesEscherichia coli ProteinsLipopolysaccharidesLptC protein, E coliMembrane ProteinsMultiprotein ComplexesProtein SubunitsVanadates

Identifiers

PMID30894744
PMCPMC6532066
OpenAlexW2925222192

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.