Evidence map›Paper›PMID 30894696›Full record

ArticleHypertension research : official journal of the Japanese Society of Hypertension2019

Acute salt loading induces sympathetic nervous system overdrive in mice lacking salt-inducible kinase 1 (SIK1).

Nuno Marques Pires, Bruno Igreja, Maria Paula Serrão, Emanuel F Matias, Eduardo Moura, Tatiana António, Filipa Lopes Campos, Laura Brion, Alejandro Bertorello, Patrício Soares-da-Silva

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In one paragraph

Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Nuno Marques PiresBIAL-Portela & Cª, S.A., R&D, Coronado (S. Romão e S. Mamede), Portugal.
Bruno IgrejaBIAL-Portela & Cª, S.A., R&D, Coronado (S. Romão e S. Mamede), Portugal.
Maria Paula SerrãoDepartment of Pharmacology & Therapeutics, Faculty of Medicine, University of Porto, Porto, Portugal.
Emanuel F MatiasDepartment of Pharmacology & Therapeutics, Faculty of Medicine, University of Porto, Porto, Portugal.
Eduardo MouraBIAL-Portela & Cª, S.A., R&D, Coronado (S. Romão e S. Mamede), Portugal.
Tatiana AntónioDepartment of Pharmacology & Therapeutics, Faculty of Medicine, University of Porto, Porto, Portugal.
Filipa Lopes CamposBIAL-Portela & Cª, S.A., R&D, Coronado (S. Romão e S. Mamede), Portugal.
Laura BrionMembrane Signaling Networks, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
Alejandro BertorelloMembrane Signaling Networks, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
Patrício Soares-da-SilvaBIAL-Portela & Cª, S.A., R&D, Coronado (S. Romão e S. Mamede), Portugal. pss@med.up.pt.
Bial (Portugal) · PTUniversidade do Porto · PTKarolinska Institutet · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Loss of salt-inducible kinase 1 (SIK1) triggers an increase in blood pressure (BP) upon a chronic high-salt intake in mice. Here, we further addressed the possible early mechanisms that may relate to the observed rise in BP in mice lacking SIK1. SIK1 knockout (sik1

Indexed as

AnimalsBenzopyransBlood PressureHypertensionImidazolesKidneyMaleMice, KnockoutProtein Serine-Threonine KinasesRenin-Angiotensin SystemSodium Chloride, DietarySympathetic Nervous SystemBenzopyransetamicastatImidazolesProtein Serine-Threonine KinasesSik1 protein, mouseSodium Chloride, DietaryDopamine β-hydroxylaseHigh-salt intakeHypertensionSIK1Sympathetic nervous system

Identifiers

PMID30894696
OpenAlexW2925191895

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.