ArticleScientific reports2019
Single-trial classification of awareness state during anesthesia by measuring critical dynamics of global brain activity.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- Time-resolved correlation of distributed brain activity tracks E-I balance and accounts for diverse scale-free phenomena.Cell reports · 2023Article
- Intraoperative Awareness in Patients Undergoing Cardiac Surgery in an Academic Center in the North of Iran.Anesthesiology and pain medicine · 2022Article
- May the 4C's be with you: an overview of complexity-inspired frameworks for analysing resting-state neuroimaging data.Journal of the Royal Society, Interface · 2022Review
- Robustness and Flexibility of Neural Function through Dynamical Criticality.Entropy (Basel, Switzerland) · 2022Review
- How general anesthetics work: from the perspective of reorganized connections within the brain.Korean journal of anesthesiology · 2022Review
- Propofol-induced Unresponsiveness Is Associated with a Brain Network Phase Transition.Anesthesiology · 2022Article
- Topological analysis of differential effects of ketamine and propofol anaesthesia on brain dynamics.Royal Society open science · 2021Article
- Explaining anaesthetic hysteresis with effect-site equilibration.British journal of anaesthesia · 2021Article
- Resistance to state transitions in responsiveness is differentially modulated by different volatile anaesthetics in male mice.British journal of anaesthesia · 2020Article
- Reconciling Current Theories of Consciousness.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Analysis of stochastic fluctuations in responsiveness is a critical step toward personalized anesthesia.eLife · 2019Article
- Finding the starter motor for the engine of consciousness.British journal of anaesthesia · 2019Article
- General Anesthesia: A Probe to Explore Consciousness.Frontiers in systems neuroscience · 2019Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 5 institutions in 3 countries.
Funding
Abstract
In daily life, in the operating room and in the laboratory, the operational way to assess wakefulness and consciousness is through responsiveness. A number of studies suggest that the awake, conscious state is not the default behavior of an assembly of neurons, but rather a very special state of activity that has to be actively maintained and curated to support its functional properties. Thus responsiveness is a feature that requires active maintenance, such as a homeostatic mechanism to balance excitation and inhibition. In this work we developed a method for monitoring such maintenance processes, focusing on a specific signature of their behavior derived from the theory of dynamical systems: stability analysis of dynamical modes. When such mechanisms are at work, their modes of activity are at marginal stability, neither damped (stable) nor exponentially growing (unstable) but rather hovering in between. We have previously shown that, conversely, under induction of anesthesia those modes become more stable and thus less responsive, then reversed upon emergence to wakefulness. We take advantage of this effect to build a single-trial classifier which detects whether a subject is awake or unconscious achieving high performance. We show that our approach can be developed into a means for intra-operative monitoring of the depth of anesthesia, an application of fundamental importance to modern clinical practice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.