ArticleScientific reports2019
Genetic differences in host infectivity affect disease spread and survival in epidemics.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- The consequences of host heterogeneity for parasite transmission depend on how host infectiousness is determined.The Journal of animal ecology · 2026Article
- Impact of genomic selection for disease resistance on the spread of infection in a simulated aquaculture population.Genetics, selection, evolution : GSE · 2026Article
- Estimation of Genetic Variance and Breeding Values for Infectious Disease Susceptibility From Simulated Longitudinal Data Using Generalized Linear Mixed Models Based on Transmission Dynamics.Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie · 2026Article
- Viral Prognosis Using Proteomics.Advances in experimental medicine and biology · 2026Review
- Article
- Marked heterogeneity in malaria infection rate in a Malian longitudinal cohort.Nature communications · 2025Article
- SIRE 2.0: a novel method for estimating polygenic host effects underlying infectious disease transmission, and analytical expressions for prediction accuracies.Genetics, selection, evolution : GSE · 2025Article
- Epidemic evolutionarily stable strategies within an age-structured host population.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Experimental Infection Models and Their Usefulness for White Spot Syndrome Virus (WSSV) Research in Shrimp.Viruses · 2024Review
- Intergenomic signatures of coevolution between Tasmanian devils and an infectious cancer.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Disease resistance and infectivity of virus susceptible and resistant common carp strains.Scientific reports · 2024Article
- Hematological and serum biochemical parameters and profiling of cytokine genes in lumpy skin disease in Vrindavani cattle.3 Biotech · 2023Article
- Evaluation of low-density SNP panels and imputation for cost-effective genomic selection in four aquaculture species.Frontiers in genetics · 2023Article
- Optimal experimental designs for estimating genetic and non-genetic effects underlying infectious disease transmission.Genetics, selection, evolution : GSE · 2022Article
- Exploring the ethics of genetic prioritisation for COVID-19 vaccines.European journal of human genetics : EJHG · 2022Review
- Leveraging Mann-Whitney U test on large-scale genetic variation data for analysing malaria genetic markers.Malaria journal · 2022Article
- Why DoesFrontiers in immunology · 2022Review
- Breeding for disease resilience: opportunities to manage polymicrobial challenge and improve commercial performance in the pig industry.CABI agriculture and bioscience · 2022Review
- Review
- Review: Livestock disease resilience: from individual to herd level.Animal : an international journal of animal bioscience · 2021Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Survival during an epidemic is partly determined by host genetics. While quantitative genetic studies typically consider survival as an indicator for disease resistance (an individual's propensity to avoid becoming infected or diseased), mortality rates of populations undergoing an epidemic are also affected by endurance (the propensity of diseased individual to survive the infection) and infectivity (i.e. the propensity of an infected individual to transmit disease). Few studies have demonstrated genetic variation in disease endurance, and no study has demonstrated genetic variation in host infectivity, despite strong evidence for considerable phenotypic variation in this trait. Here we propose an experimental design and statistical models for estimating genetic diversity in all three host traits. Using an infection model in fish we provide, for the first time, direct evidence for genetic variation in host infectivity, in addition to variation in resistance and endurance. We also demonstrate how genetic differences in these three traits contribute to survival. Our results imply that animals can evolve different disease response types affecting epidemic survival rates, with important implications for understanding and controlling epidemics.
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