Evidence map›Paper›PMID 30894565›Full record

ArticleScientific reports2019

Disturbed flow induces a sustained, stochastic NF-κB activation which may support intracranial aneurysm growth in vivo.

Daniel C Baeriswyl, Ioanna Prionisti, Tom Peach, Grigoris Tsolkas, Kok Yean Chooi, John Vardakis, Sandrine Morel, Mannekomba R Diagbouga, Philippe Bijlenga, Simon Cuhlmann and 4 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05526352 (@neurIST), which is not on this map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05526352 recruitingnot on this map

@neurIST : Informatique biomédicale intégrée Pour la Gestion Des anévrismes cérébraux

Typeobservational_patient_registrySponsorUniversity Hospital, GenevaRan2015 to 2040Enrolled20,000ConditionsIntracranial Aneurysm
3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 45 citations in OpenAlex.

  1. Review
  2. Modeling Hemodynamic Effects of the Closure Procedure of Carotid Artery Endarterectomy.International journal for numerical methods in biomedical engineering · 2025
    Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
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  11. Review
  12. Role of blood flow in endothelial functionality: a review.Frontiers in cell and developmental biology · 2023
    Review
  13. Article
  14. Article
  15. Review
  16. Hemodynamic Forces, Endothelial Mechanotransduction, and Vascular Diseases.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2022
    Article
  17. Article
  18. Review
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Daniel C BaeriswylDepartment Mechanical Engineering, University College London, London, UK.
Ioanna PrionistiDepartment Bioengineering, Imperial College London, London, UK.
Tom PeachDepartment Mechanical Engineering, University College London, London, UK.
Grigoris TsolkasDepartment Bioengineering, Imperial College London, London, UK.
Kok Yean ChooiDepartment Bioengineering, Imperial College London, London, UK.
John VardakisDepartment Mechanical Engineering, University College London, London, UK.
Sandrine MorelDepartment Pathology and Immunology, University of Geneva, Geneva, Switzerland.ORCID 0000-0003-1538-3553
Mannekomba R DiagbougaDepartment Pathology and Immunology, University of Geneva, Geneva, Switzerland.
Philippe BijlengaDepartment Clinical Neurosciences, Geneva University Hospitals, Geneva, Switzerland.ORCID 0000-0002-3586-2757
Simon CuhlmannDepartment Bioengineering, Imperial College London, London, UK.
Paul EvansDepartment Bioengineering, Imperial College London, London, UK.
Brenda R KwakDepartment Pathology and Immunology, University of Geneva, Geneva, Switzerland.ORCID 0000-0003-0015-0044
Yiannis VentikosDepartment Mechanical Engineering, University College London, London, UK.
Rob KramsDepartment Bioengineering, Imperial College London, London, UK. r.krams@qmul.ac.uk.
Imperial College London · GBUniversity College London · GBUniversity of Geneva · CHQueen Mary University of London · GBUniversity Hospital of Geneva · CH

Funding

Biotechnology and Biological Sciences Research Council BB/L015129/1British Heart Foundation RG/11/13/29055Wellcome TrustWellcome Trust 104931/Z/14/Z
6 · The paper itself

Abstract

Intracranial aneurysms are associated with disturbed velocity patterns, and chronic inflammation, but the relevance for these findings are currently unknown. Here, we show that (disturbed) shear stress induced by vortices is a sufficient condition to activate the endothelial NF-kB pathway, possibly through a mechanism of mechanosensor de-activation. We provide evidence for this statement through in-vitro live cell imaging of NF-kB in HUVECs exposed to different flow conditions, stochastic modelling of flow induced NF-kB activation and induction of disturbed flow in mouse carotid arteries. Finally, CFD and immunofluorescence on human intracranial aneurysms showed a correlation similar to the mouse vessels, suggesting that disturbed shear stress may lead to sustained NF-kB activation thereby offering an explanation for the close association between disturbed flow and intracranial aneurysms.

Indexed as

AnimalsCarotid ArteriesHumansHuman Umbilical Vein Endothelial CellsIntracranial AneurysmMiceMolecular ImagingNF-kappa BRegional Blood FlowStress, MechanicalNF-kappa B

Identifiers

PMID30894565
PMCPMC6426999
OpenAlexW2923602880

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.