ArticleScientific reports2019
Phaeobacter inhibens induces apoptosis-like programmed cell death in calcifying Emiliania huxleyi.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 40 citations in OpenAlex.
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- Cell death is a conserved innate disease resistance response of brown algae against the oomyceteiScience · 2025Article
- The impact of tropodithietic acid on microbial physiology under varying culture complexities.mSphere · 2025Article
- Integrating microbial communities into algal biotechnology: a pathway to enhanced commercialization.Frontiers in microbiology · 2025Review
- Algal methylated compounds shorten the lag phase of Phaeobacter inhibens bacteria.Nature microbiology · 2024Article
- Abundant Sulfitobacter marine bacteria protect Emiliania huxleyi algae from pathogenic bacteria.ISME communications · 2023Article
- Aerobic bacteria produce nitric oxide via denitrification and promote algal population collapse.The ISME journal · 2023Article
- Extracellular Compounds from Pathogenic BacteriumBiology · 2022Article
- Is Aging an Inevitable Characteristic of Organic Life or an Evolutionary Adaptation?Biochemistry. Biokhimiia · 2022Review
- The Small-Molecule Language of Dynamic Microbial Interactions.Annual review of microbiology · 2022Review
- Algal p-coumaric acid induces oxidative stress and siderophore biosynthesis in the bacterial symbiont Phaeobacter inhibens.Cell chemical biology · 2022Article
- Fatal affairs - conjugational transfer of a dinoflagellate-killing plasmid between marineMicrobial genomics · 2022Article
- Resolving the Microalgal Gene Landscape at the Strain Level: a Novel Hybrid Transcriptome ofApplied and environmental microbiology · 2022Article
- Structural Elucidation of Cryptic Algaecides in Marine Algal-Bacterial Symbioses by NMR Spectroscopy and MicroED.Angewandte Chemie (International ed. in English) · 2022Article
- Algicidal Bacteria: A Review of Current Knowledge and Applications to Control Harmful Algal Blooms.Frontiers in microbiology · 2022Review
- Initiation and Execution of Programmed Cell Death and Regulation of Reactive Oxygen Species in Plants.International journal of molecular sciences · 2021Review
- Bacterial Quorum-Sensing Signal Arrests Phytoplankton Cell Division and Impacts Virus-Induced Mortality.mSphere · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The model coccolithophore, Emiliania huxleyi, forms expansive blooms dominated by the calcifying cell type, which produce calcite scales called coccoliths. Blooms last several weeks, after which the calcified algal cells rapidly die, descending into the deep ocean. E. huxleyi bloom collapse is attributed to E. huxleyi viruses (EhVs) that infect and kill calcifying cells, while other E. huxleyi pathogens, such as bacteria belonging to the roseobacter clade, are overlooked. EhVs kill calcifying E. huxleyi by inducing production of bioactive viral-glycosphingolipids (vGSLs), which trigger algal programmed cell death (PCD). The roseobacter Phaeobacter inhibens was recently shown to interact with and kill the calcifying cell type of E. huxleyi, but the mechanism of algal death remains unelucidated. Here we demonstrate that P. inhibens kills calcifying E. huxleyi by inducing a highly specific type of PCD called apoptosis-like-PCD (AL-PCD). Host death can successfully be abolished in the presence of a pan-caspase inhibitor, which prevents the activation of caspase-like molecules. This finding differentiates P. inhibens and EhV pathogenesis of E. huxleyi, by demonstrating that bacterial-induced AL-PCD requires active caspase-like molecules, while the viral pathogen does not. This is the first demonstration of a bacterium inducing AL-PCD in an algal host as a killing mechanism.
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