Evidence map›Paper›PMID 30894542›Full record

ArticleNature communications2019

Optogenetic stimulation of G

Philipp Makowka, Tobias Bruegmann, Vanessa Dusend, Daniela Malan, Thomas Beiert, Michael Hesse, Bernd K Fleischmann, Philipp Sasse

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 48 citations in OpenAlex.

  1. Review
  2. Article
  3. Cardiac optogenetics: shining light on signaling pathways.Pflugers Archiv : European journal of physiology · 2023
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. A self-inactivating invertebrate opsin optically drives biased signaling toward Gβγ-dependent ion channel modulation.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  9. Review
  10. Selective optogenetic control of GNature communications · 2022
    Article
  11. Article
  12. Article
  13. Article
  14. Cardiac optogenetics: a decade of enlightenment.Nature reviews. Cardiology · 2021
    Review
  15. Optogenetic Modulation of Ion Channels by Photoreceptive Proteins.Advances in experimental medicine and biology · 2021
    Review
  16. Review
  17. Optogenetic Stimulation of GFrontiers in physiology · 2021
    Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Philipp MakowkaInstitute of Physiology I, Medical Faculty, University of Bonn, 53127, Bonn, Germany.
Tobias BruegmannInstitute of Physiology I, Medical Faculty, University of Bonn, 53127, Bonn, Germany.ORCID http://orcid.org/0000-0002-6930-9634
Vanessa DusendInstitute of Physiology I, Medical Faculty, University of Bonn, 53127, Bonn, Germany.
Daniela MalanInstitute of Physiology I, Medical Faculty, University of Bonn, 53127, Bonn, Germany.
Thomas BeiertDepartment of Internal Medicine II, University Hospital Bonn, University of Bonn, 53127, Bonn, Germany.
Michael HesseInstitute of Physiology I, Medical Faculty, University of Bonn, 53127, Bonn, Germany.
Bernd K FleischmannInstitute of Physiology I, Medical Faculty, University of Bonn, 53127, Bonn, Germany.
Philipp SasseInstitute of Physiology I, Medical Faculty, University of Bonn, 53127, Bonn, Germany. philipp.sasse@uni-bonn.de.ORCID http://orcid.org/0000-0002-8502-9472
University of Bonn · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The standard technique for investigating adrenergic effects on heart function is perfusion with pharmaceutical agonists, which does not provide high temporal or spatial precision. Herein we demonstrate that the light sensitive G

Indexed as

Light Signal TransductionAnimalsCalciumCations, DivalentCell DifferentiationCyclic AMPGene ExpressionGreen Fluorescent ProteinsGTP-Binding Protein alpha Subunits, GsHeart AtriaHeart VentriclesLightMiceMouse Embryonic Stem CellsMyocytes, CardiacOptogeneticsCalciumCations, DivalentCyclic AMPGreen Fluorescent ProteinsGTP-Binding Protein alpha Subunits, Gs

Identifiers

PMID30894542
PMCPMC6426906
OpenAlexW2923992690

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.