ArticleNature communications2019
ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression.
Erratum issuedOpen access · goldAbstract read
In one paragraph
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 115 papers.
0numbers the graph read from it
0cells of the map it votes in
115citing papers in PubMed
7.7field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
115 citing papers in PubMed, 152 citations in OpenAlex.
- Acoustoelectric nanoregulator for modulating the endoplasmic reticulum and mitochondria in cell fate regulation.Bioactive materials · 2027Article
- Proximity labeling puts ZFP36L1 as central hub for posttranscriptional regulation networks in T cells.Life science alliance · 2026Article
- A meta-interaction basis for cell-cell communication in tissues.bioRxiv : the preprint server for biology · 2026Article
- ATF4 orchestrates cancer hallmarks: Stress adaptation, metabolic reprogramming and immune suppression.iScience · 2026Review
- Targeting TMED4 enhances CD8Science advances · 2026Article
- T-Cell Exhaustion in the Tumor Microenvironment: Subcellular Dysfunction, Pan-Cancer Characteristics, and Therapeutic Interventions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Proteostasis sustains T cell differentiation potential and tumor-infiltrating lymphocyte function.Cell · 2026Article
- Lifestyle intervention is associated with attenuation of ER stress/inflammation and enhancement of naive immune cell identity in older adults with metabolic disease.bioRxiv : the preprint server for biology · 2026Article
- Metabolic and transcriptional plasticity supports CD8Immunity · 2026Article
- The roles and heterogeneity of CD8International journal of molecular medicine · 2026Review
- Endoplasmic reticulum stress in antitumor immunity and immunotherapy resistance: mechanisms and therapeutic implications.Molecular cancer · 2026Review
- ATF4: Orchestrating Cellular Stress Adaptation, Metabolism, and Immune Regulation in Health and Disease.International journal of molecular sciences · 2026Review
- S1P-S1PR1 signaling impairs CD8EMBO reports · 2026Article
- Pan-cancer analysis reveals differential PERK expression across tumour types and its potential as a therapeutic target.Discover oncology · 2026Article
- Targeting organelle function in T cells for cancer immunotherapy.Nature reviews. Immunology · 2026Review
- Proteostasis sustains T cell differentiation potential and tumor-infiltrating lymphocyte function.bioRxiv : the preprint server for biology · 2026Article
- Targeting the UPR with Small Molecules: Emerging Strategies for Immune Regulation.Molecules (Basel, Switzerland) · 2026Review
- The Transcription Factor DDIT3 Regulates Macrophage Function by Inhibiting KLF10 to Attenuate ALI/ARDS Inflammation.Inflammation · 2026Article
- Article
- Integrating T cell signaling and metabolism to enhance T cell engager responses in solid tumors.Frontiers in immunology · 2026Review
55 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
19 authors at 5 institutions in 2 countries.
Yu CaoDepartment of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, 33612, USA.ORCID http://orcid.org/0000-0003-3708-575X
Jimena Trillo-TinocoDepartment of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, 33612, USA.
Rosa A SierraDepartment of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, 33612, USA.
Carmen AnadonDepartment of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, 33612, USA.
Wenjie DaiDepartment of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, 33612, USA.
Eslam MohamedDepartment of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, 33612, USA.
Ling CenCancer Informatics Core, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, 33612, USA.
Tara L CostichDepartment of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, 33612, USA.
Anthony MaglioccoDepartment of Pathology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, 33612, USA.
Douglas MarchionDepartment of Pathology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, 33612, USA.
Richard KlarSecarna Pharmaceuticals GmbH & Co. KG, 82152, Planegg/Martinsried, Germany.
Sven MichelSecarna Pharmaceuticals GmbH & Co. KG, 82152, Planegg/Martinsried, Germany.
Frank JaschinskiSecarna Pharmaceuticals GmbH & Co. KG, 82152, Planegg/Martinsried, Germany.
Richard R ReichBiostatistics Program, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, 33612, USA.
Shikhar MehrotraDepartment of Surgery, Medical University of South Carolina, Charleston, SC, 29425, USA.
Juan R Cubillos-RuizDepartment of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, 10065, USA.
David H MunnDepartment of Pediatrics, Georgia Cancer Center, Augusta University, Augusta, GA, 30912, USA.
Jose R Conejo-GarciaDepartment of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, 33612, USA.
Paulo C RodriguezDepartment of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, 33612, USA. Paulo.Rodriguez@Moffitt.org.
Moffitt Cancer Center · USHikma Pharmaceuticals (Germany) · DEAugusta University Health · USCornell University · USMedical University of South Carolina · US
Funding
TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI KENNETH Lynn WRIGHT · 1998 to 2026
$93.5MTumor Microenvironment and MetastasisP30CA010815 · NCI · WISTAR INSTITUTE · PI Luis J Montaner · 1985 to 2026
$75.9MVascular Leukocytes Influence the Tumor MicroenvironmentR01CA124515 · NCI · WISTAR INSTITUTE · PI Jose R Conejo-Garcia · 2007 to 2026
$7.1MReprogramming the TME for immunogenic antigen-presentationR01CA103320 · NCI · MEDICAL COLLEGE OF GEORGIA (MCG) · PI MUNN, DAVID H. · 2003 to 2024
$6.0MRapid Exoproteome Antigen Profiling of antibodies produced in the ovarian cancer microenvironmentU01CA232758 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI CONEJO-GARCIA, JOSE R · 2018 to 2022
$4.1MInitiation and Evolution of the Ovarian Cancer MicroenvironmentR01CA157664 · NCI · WISTAR INSTITUTE · PI CONEJO-GARCIA, JOSE R · 2011 to 2020
$3.8MEffects of Common Polymorphisms in Immune Sensors in Tumor ImmunosurveillanceR01CA178687 · NCI · WISTAR INSTITUTE · PI CONEJO-GARCIA, JOSE R · 2013 to 2017
$1.9MStress Pathways in Tumors Drive Global MDSC Activity and Survival through ChopR01CA184185 · NCI · LSU HEALTH SCIENCES CENTER · PI RODRIGUEZ, PAULO CESAR · 2015 to 2019
$1.8MPTEN, Tregs and MDSCs in the tumor microenvironmentR01CA211229 · NCI · AUGUSTA UNIVERSITY · PI MUNN, DAVID H. · 2017 to 2021
$1.7MNCI NIH HHS P30 CA010815NCI NIH HHS P30 CA076292NCI NIH HHS R01 CA103320NCI NIH HHS R01 CA124515NCI NIH HHS R01 CA157664NCI NIH HHS R01 CA178687NCI NIH HHS R01 CA184185NCI NIH HHS R01 CA211229NCI NIH HHS U01 CA232758NIH HHS R01CA103320NIH HHS R01CA124515NIH HHS R01CA157664NIH HHS R01CA178687NIH HHS R01CA184185NIH HHS R01CA211229NIH HHS U01CA232758
Abstract
Understanding the intrinsic mediators that render CD8
Indexed as
Activating Transcription Factor 4Adoptive TransferAnimalsCarcinoma, Ovarian EpithelialCD8-Positive T-LymphocytesCell Line, TumoreIF-2 KinaseEndoplasmic Reticulum StressFemaleGene Expression Regulation, NeoplasticHumansImmunity, CellularLymphocytes, Tumor-InfiltratingMiceMice, KnockoutOvarian NeoplasmsActivating Transcription Factor 4ATF4 protein, humanDDIT3 protein, humanEIF2AK3 protein, humaneIF-2 KinaseRNA, Small InterferingT-bet Transcription FactorT-Box Domain ProteinsTranscription Factor CHOP
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.