ArticleProceedings of the National Academy of Sciences of the United States of America2019
Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers.
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88citing papers in PubMed
12.1field-weighted citation impact, top 1% of its field
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Who cites it
88 citing papers in PubMed, 134 citations in OpenAlex.
- Kaempferol activity onPharmaceutical biology · 2026Article
- Identification, Structure-Activity Relationship (SAR), and Biological Evaluation of New Chemical Series as Malaria ParasiteACS omega · 2026Article
- In Vivo Efficacy and Biochemical Target Engagement of a Chromene-Based Inhibitor of Trypanosoma cruzi Lysyl-tRNA Synthetase.Journal of medicinal chemistry · 2026Article
- Structure-Activity Relationship Study of Anti-Cryptosporidium Benzoxaboroles Yields Enhanced Potency and Curative Efficacy.Journal of medicinal chemistry · 2026Article
- Late-Stage Functionalization via Thianthrenation: A Reaction Enabling Rapid Preparation of Drug Beads for Chemical Pulldown.Journal of medicinal chemistry · 2026Article
- Structure-Guided Optimization of Novel Inhibitors ofJournal of medicinal chemistry · 2026Article
- Genomic heterogeneity of NAD(P)H dehydrogenase predisposes Cryptosporidium to clofazimine resistance.Nature microbiology · 2026Article
- Insights into the lifecycle of Cryptosporidium and compounds targeting developmental stages.Current opinion in microbiology · 2026Review
- Genetic Manipulation of Cryptosporidium parvum.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Article
- Widespread genomic heterogeneity at the type II NAD(P)H dehydrogenase locus predisposesbioRxiv : the preprint server for biology · 2025Article
- Design and Development of Lysyl tRNA Synthetase Inhibitors, for the Treatment of Tuberculosis.Journal of medicinal chemistry · 2025Article
- Antitrypanosomal quinazolines targeting lysyl-tRNA synthetase show partial efficacy in a mouse model of acute Chagas disease.Science translational medicine · 2025Article
- Aminoisothiazolamides, a new class of potent inhibitors of lysyl-tRNA synthetase.Pest management science · 2025Article
- Versatile Imidazole Scaffold with Potent Activity against Multiple Apicomplexan Parasites.ACS infectious diseases · 2025Article
- Vesicular mechanisms of drug resistance in apicomplexan parasites.Microbiology and molecular biology reviews : MMBR · 2025Review
- The Importance of Murine Models in Determining In Vivo Pharmacokinetics, Safety, and Efficacy in Antimalarial Drug Discovery.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Discovery of an Orally Efficacious Pyrazolo[3,4-Journal of medicinal chemistry · 2025Article
- Antimalarial Drug Discovery from Natural and Synthetic Sources.Current medicinal chemistry · 2025Review
- Molecular pathogenesis of Cryptosporidium and advancements in therapeutic interventions.Parasite (Paris, France) · 2025Review
28 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
77 authors at 16 institutions in 7 countries.
Beatriz BaragañaWellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom.
Barbara ForteWellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom.
Ryan ChoiSeattle Structural Genomics Center for Infectious Disease, Seattle, WA 98109.
Stephen Nakazawa HewittSeattle Structural Genomics Center for Infectious Disease, Seattle, WA 98109.
Juan A Bueren-CalabuigWellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom.
João Pedro PiscoWellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom.ORCID 0000-0001-6763-7354
Caroline PeetWellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom.
David M DranowSeattle Structural Genomics Center for Infectious Disease, Seattle, WA 98109.
David A RobinsonWellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom.
Chimed JansenWellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom.
Neil R NorcrossWellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom.
Sumiti VinayakCenter for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602.
Mark AndersonWellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom.
Carrie F BrooksCenter for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602.
Caitlin A CooperCenter for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602.
Sebastian DamerowWellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom.
Michael DelvesDepartment of Life Sciences, Imperial College, South Kensington, SW7 2AZ London, United Kingdom.
Karen DowersWellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom.
James DuffyMedicines for Malaria Venture, 1215 Geneva 15, Switzerland.
Thomas E EdwardsSeattle Structural Genomics Center for Infectious Disease, Seattle, WA 98109.
Irene HallyburtonWellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom.
Benjamin G HorstSeattle Structural Genomics Center for Infectious Disease, Seattle, WA 98109.
Matthew A HulversonDivision of Allergy and Infectious Diseases, University of Washington, Seattle, WA 98109.
Liam FergusonWellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom.
María Belén Jiménez-DíazThe Art of Discovery, 48160 Derio, Bizkaia, Basque Country, Spain.
Rajiv S JumaniDepartment of Medicine, University of Vermont, Burlington, VT 05405.
Donald D LorimerSeattle Structural Genomics Center for Infectious Disease, Seattle, WA 98109.
Melissa S LoveBiology Department, Calibr at Scripps Research, La Jolla, CA 92037.
Steven MaherCenter for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602.
Holly MatthewsDepartment of Life Sciences, Imperial College, South Kensington, SW7 2AZ London, United Kingdom.
Case W McNamaraBiology Department, Calibr at Scripps Research, La Jolla, CA 92037.
Peter MillerDepartment of Medicine, University of Vermont, Burlington, VT 05405.
Sandra O'NeillWellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom.
Kayode K OjoDivision of Allergy and Infectious Diseases, University of Washington, Seattle, WA 98109.ORCID 0000-0002-2007-2170
Maria Osuna-CabelloWellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom.
Erika PintoWellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom.
John PostWellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom.
Jennifer RileyWellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom.
Matthias RottmannDepartment of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, CH-4002 Basel, Switzerland.
Laura M SanzDiseases of the Developing World, Global Health, GlaxoSmithKline, 28760 Tres Cantos, Madrid, Spain.
Paul ScullionWellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom.
Arvind SharmaStructural Parasitology Group, International Centre for Genetic Engineering and Biotechnology, 110067 New Delhi, India.ORCID 0000-0002-7029-9867
Sharon M ShepherdWellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom.
Yoko ShishikuraWellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom.
Frederick R C SimeonsWellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom.
Erin E StebbinsDepartment of Medicine, University of Vermont, Burlington, VT 05405.
Laste StojanovskiWellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom.
Ursula StraschilDepartment of Life Sciences, Imperial College, South Kensington, SW7 2AZ London, United Kingdom.
Fabio K TamakiWellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom.
Jevgenia TamjarWellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom.
Leah S TorrieWellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom.
Amélie VantauxMalaria Molecular Epidemiology Unit, Institut Pasteur du Cambodge, 12 201 Phnom Penh, Cambodia.
Benoît WitkowskiMalaria Molecular Epidemiology Unit, Institut Pasteur du Cambodge, 12 201 Phnom Penh, Cambodia.
Sergio WittlinDepartment of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, CH-4002 Basel, Switzerland.
Manickam YogavelStructural Parasitology Group, International Centre for Genetic Engineering and Biotechnology, 110067 New Delhi, India.
Fabio ZuccottoWellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom.
Iñigo Angulo-BarturenThe Art of Discovery, 48160 Derio, Bizkaia, Basque Country, Spain.
Robert SindenDepartment of Life Sciences, Imperial College, South Kensington, SW7 2AZ London, United Kingdom.
Jake BaumDepartment of Life Sciences, Imperial College, South Kensington, SW7 2AZ London, United Kingdom.ORCID 0000-0002-0275-352X
Francisco-Javier GamoDiseases of the Developing World, Global Health, GlaxoSmithKline, 28760 Tres Cantos, Madrid, Spain.
Pascal MäserDepartment of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, CH-4002 Basel, Switzerland.
Dennis E KyleCenter for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602.
Elizabeth A WinzelerSkaggs School of Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093.
Peter J MylerSeattle Structural Genomics Center for Infectious Disease, Seattle, WA 98109.
Paul G WyattWellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom.
David FloydStructural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada.
David MatthewsStructural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada.
Amit SharmaStructural Parasitology Group, International Centre for Genetic Engineering and Biotechnology, 110067 New Delhi, India.
Boris StriepenCenter for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602.
Christopher D HustonDepartment of Medicine, University of Vermont, Burlington, VT 05405.
David W GrayWellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom.
Alan H FairlambWellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom.ORCID 0000-0001-5134-0329
Andrei V PisliakovComputational Biology, School of Life Sciences, University of Dundee, DD1 5EH Dundee, United Kingdom.
Chris WalpoleStructural Genomics Consortium, Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada.
Kevin D ReadWellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom.
Wesley C Van VoorhisSeattle Structural Genomics Center for Infectious Disease, Seattle, WA 98109.
Ian H GilbertWellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom; i.h.gilbert@dundee.ac.uk.ORCID 0000-0002-5238-1314
University of Dundee · GBUniversity of Georgia · USUniversity of Washington · USImperial College London · GBUniversity of Vermont · USBeryllium (United States) · USInternational Centre for Genetic Engineering and Biotechnology · INSwiss Tropical and Public Health Institute · CHGlaxoSmithKline (Spain) · ESInstitut Pasteur du Cambodge · KHScripps Research Institute · USUniversity of Toronto · CAInfectious Disease Research Institute · USMcGill University Health Centre · CAMedicines for Malaria Venture · CHUniversity of California San Diego · US
Funding
Using Dengue Controlled Human Infection Model to Identify Adaptive Immune Correlates of ProtectionP20GM125498 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI Ellen Kozelka · 2018 to 2026
$24.9MVERMONT IMMUNOBIOLOIGY/ INFECTIOUS DISEASES CENTERP20RR021905 · NCRR · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI BUDD, RALPH C · 2006 to 2011
$14.5MVermont Immunology/Infectious Diseases CenterP30GM118228 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI BUDD, RALPH C · 2016 to 2021
$6.8MGenetic Analysis of CryptosporidiumR01AI112427 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI STRIEPEN, BORIS · 2014 to 2023
$4.2MDiscovery of chemically validated malaria liver stage targetsR01AI090141 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WINZELER, ELIZABETH A · 2011 to 2019
$3.4MDefining the targets of broad intervention antimalarial agentsR01AI103058 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WINZELER, ELIZABETH A · 2013 to 2016
$2.6MGenetic Analysis of CryptosporidiumR37AI112427 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI BORIS STRIEPEN · 2024 to 2026
$1.5MCoformulation of bumped kinase inhibitors with Artemisinin combination therapy will stop widespread transmission of artemisinin-resistant malaria strainsR21AI123690 · NIAID · UNIVERSITY OF WASHINGTON · PI OJO, KAYODE K · 2017 to 2018
$490kContinuous in vitro culture and treatment of Cryptosporidium using small molecule differentiation inhibitorsR21AI130807 · NIAID · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI HUSTON, CHRISTOPHER D · 2017 to 2018
$424kNCRR NIH HHS P20 RR021905NIAID NIH HHS HHSN272201200025CNIAID NIH HHS R01 AI090141NIAID NIH HHS R01 AI103058NIAID NIH HHS R21 AI123690NIAID NIH HHS R21 AI130807NIAID NIH HHS R37 AI112427NIGMS NIH HHS P20 GM125498NIGMS NIH HHS P30 GM118228Wellcome Trust 094090Wellcome Trust 203134Wellcome Trust 203134/Z/16/Z
Abstract
Malaria and cryptosporidiosis, caused by apicomplexan parasites, remain major drivers of global child mortality. New drugs for the treatment of malaria and cryptosporidiosis, in particular, are of high priority; however, there are few chemically validated targets. The natural product cladosporin is active against blood- and liver-stage
Indexed as
CryptosporidiosisMalaria, FalciparumAnimalsCryptosporidium parvumDisease Models, AnimalEnzyme InhibitorsHumansLysine-tRNA LigaseMice, SCIDPlasmodium falciparumProtozoan ProteinsEnzyme InhibitorsLysine-tRNA LigaseProtozoan ProteinscryptosporidiosismalariatRNA synthetase
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