ArticleProceedings of the National Academy of Sciences of the United States of America2019
Strong triaxial coupling and anomalous Poisson effect in collagen networks.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
39 citing papers in PubMed, 95 citations in OpenAlex.
- Mechanical cues of an interpenetrating polysaccharide matrix regulate self-assembly of collagen fibers.Science advances · 2026Article
- 3D-Printing-Assisted, Microfabricated Devices Reveal Hierarchical and Temporal Mechanosensing in High-Density Fibroblast Culture.ACS nano · 2026Article
- Compression-Tension-Asymmetry and Stiffness Nonlinearity of Collagen-Matrigel Composite Hydrogels.Advanced healthcare materials · 2026Article
- Tension-induced directional migration of hepatic stellate cells potentially coordinates liver fibrosis progression.Nature biomedical engineering · 2025Article
- Focal adhesion in the tumour metastasis: from molecular mechanisms to therapeutic targets.Biomarker research · 2025Review
- Mechanical Models of Collagen Networks for Understanding Changes in the Failure Properties of Aging Skin.Journal of biomechanical engineering · 2024Article
- Unexpected softening of a fibrous matrix by contracting inclusions.Acta biomaterialia · 2024Article
- Modeling the extracellular matrix in cell migration and morphogenesis: a guide for the curious biologist.Frontiers in cell and developmental biology · 2024Review
- Asymmetry of tensile versus compressive elasticity and permeability contributes to the regulation of exchanges in collagen gels.Science advances · 2023Article
- Volume Loss and Recovery in Bovine Knee Meniscus Loaded in Circumferential Tension.Journal of biomechanical engineering · 2023Article
- Local response and emerging nonlinear elastic length scale in biopolymer matrices.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Multiscale mechanical characterization and computational modeling of fibrin gels.Acta biomaterialia · 2023Article
- Synthetic fibrous hydrogels as a platform to decipher cell-matrix mechanical interactions.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Polarized interfacial tension induces collective migration of cells, as a cluster, in a 3D tissue.Biophysical journal · 2022Article
- Glycosaminoglycans modulate long-range mechanical communication between cells in collagen networks.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Multiscale Computational Model Predicts Mouse Skin Kinematics Under Tensile Loading.Journal of biomechanical engineering · 2022Article
- Cell-matrix reciprocity in 3D culture models with nonlinear elasticity.Bioactive materials · 2022Review
- Materials science and mechanosensitivity of living matter.Applied physics reviews · 2022Review
- Multiscale mechanobiology: Coupling models of adhesion kinetics and nonlinear tissue mechanics.Biophysical journal · 2022Article
- Collective Cell Migration on Collagen-I Networks: The Impact of Matrix Viscoelasticity.Frontiers in cell and developmental biology · 2022Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
While cells within tissues generate and sense 3D states of strain, the current understanding of the mechanics of fibrous extracellular matrices (ECMs) stems mainly from uniaxial, biaxial, and shear tests. Here, we demonstrate that the multiaxial deformations of fiber networks in 3D cannot be inferred solely based on these tests. The interdependence of the three principal strains gives rise to anomalous ratios of biaxial to uniaxial stiffness between 8 and 9 and apparent Poisson's ratios larger than 1. These observations are explained using a microstructural network model and a coarse-grained constitutive framework that predicts the network Poisson effect and stress-strain responses in uniaxial, biaxial, and triaxial modes of deformation as a function of the microstructural properties of the network, including fiber mechanics and pore size of the network. Using this theoretical approach, we found that accounting for the Poisson effect leads to a 100-fold increase in the perceived elastic stiffness of thin collagen samples in extension tests, reconciling the seemingly disparate measurements of the stiffness of collagen networks using different methods. We applied our framework to study the formation of fiber tracts induced by cellular forces. In vitro experiments with low-density networks showed that the anomalous Poisson effect facilitates higher densification of fibrous tracts, associated with the invasion of cancerous acinar cells. The approach developed here can be used to model the evolving mechanics of ECM during cancer invasion and fibrosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.