ArticleThe Journal of biological chemistry2019
KGF-1 accelerates wound contraction through the TGF-β1/Smad signaling pathway in a double-paracrine manner.
Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Evaluation of Nile Tilapia (ACS biomaterials science & engineering · 2026Pooled it
- Keratinocytes: A key player in skin immunity and their emerging roles in secondary lymphedema.JID innovations : skin science from molecules to population health · 2026Review
- Cell-Laden Gel Biomimetic Skin Promotes Full-Thickness Skin Wound Regeneration.Gels (Basel, Switzerland) · 2026Article
- FGF7 mitigates airway inflammation and epithelial injury in cigarette smoke-induced COPD model.Frontiers in immunology · 2026Article
- Unraveling the Mechanisms of Diabetic Wounds: Insights into Pathogenesis and Advanced Treatment Strategies.Current diabetes reviews · 2026Review
- Molecular Mechanisms of Wound Healing: The Role of Medicinal Plants.Life (Basel, Switzerland) · 2025Review
- Cell migration in diabetic wound healing: Molecular mechanisms and therapeutic strategies (Review).International journal of molecular medicine · 2025Review
- The Role of miR-138 in Cardiovascular Diseases.BioMed research international · 2025Review
- [Role of Fibroblast Growth Factor 7 in Craniomaxillofacial Development].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2024Review
- Sea food by-products valorization for biomedical applications: evaluation of their wound regeneration capabilities in anFrontiers in veterinary science · 2024Article
- Human Serum Albumin/Selenium Complex Nanoparticles Protect the Skin from Photoaging Injury.International journal of nanomedicine · 2024Article
- Radioprotective countermeasures for radiation injury (Review).Molecular medicine reports · 2023Review
- [Research progress of infrared light promoting wound healing].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2022Review
- [Research advances on interleukin-6 in hypertrophic scar formation].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2022Review
- PRRX1 is a master transcription factor of stromal fibroblasts for myofibroblastic lineage progression.Nature communications · 2022Article
- PDGF-BB-derived supramolecular hydrogel for promoting skin wound healing.Journal of nanobiotechnology · 2022Article
- Supraphysiological testosterone supplementation improves granulation tissue maturation through angiogenesis in the early phase of a cutaneous wound healing model in rats.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022Article
- Investigations on the Wound Healing Potential of Tilapia Piscidin (TP)2-5 and TP2-6.Marine drugs · 2022Article
- Roles of the fibroblast growth factor signal transduction system in tissue injury repair.Burns & trauma · 2022Review
- Keratinocyte and Fibroblast Wound Healing In Vitro Is Repressed by Non-Optimal Conditions but the Reparative Potential Can Be Improved by Water-Filtered Infrared A.Biomedicines · 2021Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
KGF-1 plays an important role in the wound healing process. Loss of the KGF-1 gene in diabetic mice attenuated the process of wound contraction, suggesting that KGF-1 contributes to wound contraction. However, the mechanism remains unclear. To investigate the role of KGF-1 in diabetic wound contraction, we established a keratinocyte-fibroblast co-culture system. Concentrations of transforming growth factor β1 (TGF-β1) in conditioned supernatant treated with KGF-1 (KGF-1 group), tk;4KGF-1-neutralizing antibody (anti-KGF-1 group), TGF-β1 (TGF-β1tk;1 group), KGF-1 and TGF-β1-neutralizing antibody (KGF-1 + anti-TGF-β1 group) were tested by ELISA. Conditioned medium was added to fibroblast-populated collagen lattice (FPCL) to investigate the effect of KGF-1 on fibroblastqj contraction. TGF-β1, Col-I, p-Smad2, p-Smad3, and α-smooth muscle actin (α-SMA) were examined by Western blotting. A diabetic rat wound model was utilized to evaluate wound morphology, histology, immunohistochemistry, and protein expression in wound tissue after treatment with KGF-1. ELISA assays revealed that the concentration of TGF-β1 in the conditioned supernatant in the KGF-1 group was significantly higher. The contractile capacity of FPCL stimulated by conditioned medium derived from the KGF-1 group was significantly elevated; however, the contractile activity of FPCL induced by KGF-1 was attenuated by TGF-β1-neutralizing antibody. The Western blot results suggest that KGF-1 is able to stimulate TGF-β1 activation with increased Col-I, p-Smad2, p-Smad3, and α-SMA expression. Diabetic wounds treated with KGF-1 had a higher degree of contraction with significantly higher expression of TGF-β1, Col-I, p-Smad2, p-Smad3, and α-SMA. Our findings demonstrate that KGF-1 promotes fibroblast contraction and accelerates wound contraction via the TGF-β1/Smad signaling pathway in a double-paracrine manner.
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Registered trials
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