Evidence map›Paper›PMID 30894405›Full record

ArticleEMBO reports2019

Retinoic acid-induced autoantigen-specific type 1 regulatory T cells suppress autoimmunity.

Mathilde Raverdeau, Maria Christofi, Anna Malara, Mieszko M Wilk, Alicja Misiak, Lucia Kuffova, Tian Yu, Aoife M McGinley, Shauna M Quinn, Chandirasegaran Massilamany and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in EMBO reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 36 citations in OpenAlex.

  1. Retinoic acid in health and disease.Signal transduction and targeted therapy · 2026
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  12. From bench to bedside: targeting lymphocyte activation gene 3 as a therapeutic strategy for autoimmune diseases.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023
    Review
  13. Tolerogenic dendritic cells generatedFrontiers in immunology · 2023
    Article
  14. [DNAM-1 regulates the proliferation and function of T regulatory type 1 cellsNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 4 countries.

Mathilde RaverdeauSchool of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
Maria ChristofiSection of Immunity, Infection and Inflammation (Ocular Immunology), School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.
Anna MalaraSchool of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
Mieszko M WilkSchool of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
Alicja MisiakSchool of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
Lucia KuffovaSection of Immunity, Infection and Inflammation (Ocular Immunology), School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.
Tian YuSection of Immunity, Infection and Inflammation (Ocular Immunology), School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.
Aoife M McGinleySchool of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
Shauna M QuinnSchool of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
Chandirasegaran MassilamanySchool of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, NE, USA.
Jay ReddySchool of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, NE, USA.
John V ForresterSection of Immunity, Infection and Inflammation (Ocular Immunology), School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.
Kingston Hg MillsSchool of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland kingston.mills@tcd.ie.ORCID 0000-0003-3646-8222
Trinity College Dublin · IEUniversity of Aberdeen · GBUniversity of Nebraska–Lincoln · USLions Eye Institute · AU

Funding

Chief Scientist Office ETM/351
6 · The paper itself

Abstract

Regulatory T (Treg) cells help to maintain tolerance and prevent the development of autoimmune diseases. Retinoic acid (RA) can promote peripheral conversion of naïve T cells into Foxp3

Indexed as

AnimalsAutoantigensAutoimmunityEncephalomyelitis, Autoimmune, ExperimentalFemaleForkhead Transcription FactorsInterleukin-10Interleukin-17MiceMice, Inbred C57BLTh17 CellsTh1 CellsT-Lymphocytes, RegulatoryTretinoinAutoantigensForkhead Transcription FactorsInterleukin-10Interleukin-17Tretinoinautoimmune diseaseimmune suppressionregulatory T cellretinoic acidTh17 cell

Identifiers

PMID30894405
PMCPMC6500997
OpenAlexW2923318414

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.