Evidence map›Paper›PMID 30894404›Full record

ArticleMolecular pharmacology2019

Human GPRC6A Mediates Testosterone-Induced Mitogen-Activated Protein Kinases and mTORC1 Signaling in Prostate Cancer Cells.

Ruisong Ye, Min Pi, Mohammed M Nooh, Suleiman W Bahout, L Darryl Quarles

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 33 citations in OpenAlex.

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  15. Endocrine Disruptors and Prostate Cancer.International journal of molecular sciences · 2022
    Review
  16. Article
  17. Diverse role of androgen action in human breast cancer.Endocrine oncology (Bristol, England) · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Ruisong YeDepartments of Medicine (R.Y., M.P., L.D.Q.) and Pharmacology (S.W.B.), University of Tennessee Health Science Center, Memphis, Tennessee; and Department of Biochemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt (M.M.N.).
Min PiDepartments of Medicine (R.Y., M.P., L.D.Q.) and Pharmacology (S.W.B.), University of Tennessee Health Science Center, Memphis, Tennessee; and Department of Biochemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt (M.M.N.) mpi@uthsc.edu.
Mohammed M NoohDepartments of Medicine (R.Y., M.P., L.D.Q.) and Pharmacology (S.W.B.), University of Tennessee Health Science Center, Memphis, Tennessee; and Department of Biochemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt (M.M.N.).
Suleiman W BahoutDepartments of Medicine (R.Y., M.P., L.D.Q.) and Pharmacology (S.W.B.), University of Tennessee Health Science Center, Memphis, Tennessee; and Department of Biochemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt (M.M.N.).
L Darryl QuarlesDepartments of Medicine (R.Y., M.P., L.D.Q.) and Pharmacology (S.W.B.), University of Tennessee Health Science Center, Memphis, Tennessee; and Department of Biochemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt (M.M.N.) dquarles@uthsc.edu.
Cairo University · EGUniversity of Tennessee Health Science Center · US

Funding

PHARMACOLOGICALLY INDUCED NEO-OSTEOGENESISR01AR037308 · NIAMS · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI QUARLES, L DARRYL · 1991 to 2009
$3.3M
NIAMS NIH HHS R01 AR037308
6 · The paper itself

Abstract

G protein-coupled receptor family C group 6 member A (GPRC6A) is activated by testosterone and modulates prostate cancer progression. Most humans have a GPRC6A variant that contains a recently evolved KGKY insertion/deletion in the third intracellular loop (ICL3) (designated as GPRC6A

Indexed as

AnimalsAutophagyCell Line, TumorCell MembraneCell ProliferationExtracellular Signal-Regulated MAP KinasesHEK293 CellsHumansLigandsMaleMechanistic Target of Rapamycin Complex 1MiceMitogen-Activated Protein KinasesPC-3 CellsProstatic NeoplasmsProto-Oncogene Proteins c-aktExtracellular Signal-Regulated MAP KinasesGPRC6A protein, humanLigandsMechanistic Target of Rapamycin Complex 1Mitogen-Activated Protein KinasesProto-Oncogene Proteins c-aktReceptors, G-Protein-CoupledRibosomal Protein S6 Kinases, 70-kDaTestosterone

Identifiers

PMID30894404
PMCPMC6474324
OpenAlexW2924596877

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.