ArticleDiabetes2019
Celastrol Reduces Obesity in MC4R Deficiency and Stimulates Sympathetic Nerve Activity Affecting Metabolic and Cardiovascular Functions.
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Article in Diabetes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
What it found
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Who cites it
23 citing papers in PubMed, 34 citations in OpenAlex.
- Synthesis of withaferin a derivatives and exploratory evaluation of weight reduction and fasting blood glucose in DIO mice.RSC advances · 2026Article
- Celastrol Attenuates Doxorubicin-Induced Heart Failure by Preserving Mitochondrial Integrity and Suppressing Oxidative Stress and Is Accompanied by Changes in Gut Microbiota.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Acute anti-obesity treatment with celastrol reduces body weight, cerebral inflammation and metabolic imbalances in mice.Molecular medicine (Cambridge, Mass.) · 2026Article
- Adipocyte-Derived Exosomal miR-5099 Mitigates M1 Macrophage Polarization and Adipose Inflammation via c-Met/NF-κB Axis to Improve Metabolic Health.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Loss of melanocortin receptor accessory protein 2 in melanocortin-4 receptor neurons protect from obesity-associated autonomic and cardiovascular dysfunctions.Cardiovascular research · 2025Article
- Efficacy of celastrol-supplemented diet in overweight and obese dogs: a 24-week randomized controlled trial.Frontiers in veterinary science · 2025Article
- PROTAC-mediated NR4A1 degradation as a novel strategy for cancer immunotherapy.The Journal of experimental medicine · 2024Article
- Role of Leptin in Obesity, Cardiovascular Disease, and Type 2 Diabetes.International journal of molecular sciences · 2024Review
- Mechanisms of and Potential Medications for Oxidative Stress in Ovarian Granulosa Cells: A Review.International journal of molecular sciences · 2023Review
- Celastrol: A Promising Agent Fighting against Cardiovascular Diseases.Antioxidants (Basel, Switzerland) · 2022Review
- Neuroprotective Effects of Celastrol in Neurodegenerative Diseases-Unscramble Its Major Mechanisms of Action and Targets.Aging and disease · 2022Review
- Recent evidence in support of traditional chinese medicine to restore normal leptin function in simple obesity.Heliyon · 2022Review
- Celastrol Inhibited Human Esophageal Cancer by Activating DR5-Dependent Extrinsic and Noxa/Bim-Dependent Intrinsic Apoptosis.Frontiers in pharmacology · 2022Article
- Histone deacetylase 6 inhibition restores leptin sensitivity and reduces obesity.Nature metabolism · 2022Article
- Celastrol: An Update on Its Hepatoprotective Properties and the Linked Molecular Mechanisms.Frontiers in pharmacology · 2022Review
- Celastrol inhibits the proliferation and migration of MCF-7 cells through the leptin-triggered PI3K/AKT pathway.Computational and structural biotechnology journal · 2022Article
- PERK in POMC neurons connects celastrol with metabolism.JCI insight · 2021Article
- Anti-obesity effects ofCanadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2021Article
- Celastrol targets adenylyl cyclase-associated protein 1 to reduce macrophages-mediated inflammation and ameliorates high fat diet-induced metabolic syndrome in mice.Acta pharmaceutica Sinica. B · 2021Article
- Celastrol inhibits intestinal lipid absorption by reprofiling the gut microbiota to attenuate high-fat diet-induced obesity.iScience · 2021Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Kenji SaitoDepartment of Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA.
Kevin C DavisDepartment of Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA.
Donald A MorganDepartment of Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA.
Brandon A TothDepartment of Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA.
Jingwei JiangDepartment of Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA.
Uday SinghDepartment of Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA.
Eric D BerglundAdvanced Imaging Research Center and Department of Pharmacology, UT Southwestern Medical Center, Dallas, TX.
Justin L GrobeDepartment of Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA.
Kamal RahmouniDepartment of Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA.ORCID 0000-0001-5136-6748
Huxing CuiDepartment of Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA huxing-cui@uiowa.edu.ORCID 0000-0002-8627-8534
University of Iowa · USAdvanced Imaging Research (United States) · US
Funding
Role of the brain Renin-Angiotensin Sys. in Cardiovas and Metabolic RegulationP01HL084207 · NHLBI · UNIVERSITY OF IOWA · PI GROBE, JUSTIN L · 2007 to 2022
$30.2MPROGRAM IN HEMOSTASIS AND THROMBOSIS FOR ACADEMICT32HL007344 · NHLBI · UNIVERSITY OF IOWA · PI Anil Kumar Chauhan, Steven R Lentz · 1985 to 2026
$6.5MInteraction between leptin and angiotensin in the pathogenesis of obesity-hypertensionR01HL134850 · NHLBI · UNIVERSITY OF IOWA · PI Justin L Grobe · 2017 to 2026
$4.4MLateral Hypothalamic Regulation of Sympathetic Nerve Activity and Blood PressureR01HL127673 · NHLBI · UNIVERSITY OF IOWA · PI CUI, HUXING · 2016 to 2020
$2.0MBehavioral characterization of humanized mouse model of eating disorderR21MH109920 · NIMH · UNIVERSITY OF IOWA · PI CUI, HUXING · 2016 to 2017
$419kNeuronal Mechanisms of Obesity-Induced HypertensionI01BX004249 · VA · IOWA CITY VA MEDICAL CENTER · PI KAMAL RAHMOUNI · 2019 to 2026
–BLRD VA I01 BX004249NHLBI NIH HHS P01 HL084207NHLBI NIH HHS R01 HL127673NHLBI NIH HHS R01 HL134850NHLBI NIH HHS T32 HL007344NIMH NIH HHS R21 MH109920
Abstract
Leptin resistance is a hallmark of obesity with unclear etiology. Celastrol, a compound found in the roots of the
Indexed as
Adipose Tissue, BrownAnimalsArterial PressureBasal MetabolismBody WeightCytokinesDiet, High-FatDisease Models, AnimalEatingEndoplasmic Reticulum StressEnergy MetabolismInflammationKidneyMiceMice, KnockoutObesitycelastrolCytokinesleptin receptor, mouseMC4R protein, mousePentacyclic TriterpenesReceptor, Melanocortin, Type 4Receptors, LeptinTriterpenes
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.