Evidence map›Paper›PMID 30894334›Full record

ArticleNeuroImage2019

Combining heterogeneous data sources for neuroimaging based diagnosis: re-weighting and selecting what is important.

Michele Donini, João M Monteiro, Massimiliano Pontil, Tim Hahn, Andreas J Fallgatter, John Shawe-Taylor, Janaina Mourão-Miranda, Alzheimer's Disease Neuroimaging Initiative

Abstract read
In one paragraph

Article in NeuroImage, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Michele DoniniComputational Statistics and Machine Learning (CSML), Istituto Italiano di Tecnologia, Genova, Italy. Electronic address: donini.michele@gmail.com.
João M MonteiroMax Planck University College London Centre for Computational Psychiatry and Ageing Research, University College London, UK; Department of Computer Science, University College London, United Kingdom.
Massimiliano PontilComputational Statistics and Machine Learning (CSML), Istituto Italiano di Tecnologia, Genova, Italy; Department of Computer Science, University College London, United Kingdom.
Tim HahnDepartment of Psychiatry and Psychotherapy, University of Münster, Germany.
Andreas J FallgatterDepartment of Psychiatry and Psychotherapy, University Hospital Tuebingen, Germany.
John Shawe-TaylorDepartment of Computer Science, University College London, United Kingdom.
Janaina Mourão-MirandaMax Planck University College London Centre for Computational Psychiatry and Ageing Research, University College London, UK; Centre for Medical Image Computing, Department of Computer Science, University College London, UK.
Alzheimer's Disease Neuroimaging Initiative

Funding

Wellcome Trust
6 · The paper itself

Abstract

Combining neuroimaging and clinical information for diagnosis, as for example behavioral tasks and genetics characteristics, is potentially beneficial but presents challenges in terms of finding the best data representation for the different sources of information. Their simple combination usually does not provide an improvement if compared with using the best source alone. In this paper, we proposed a framework based on a recent multiple kernel learning algorithm called EasyMKL and we investigated the benefits of this approach for diagnosing two different mental health diseases. The well known Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset tackling the Alzheimer Disease (AD) patients versus healthy controls classification task, and a second dataset tackling the task of classifying an heterogeneous group of depressed patients versus healthy controls. We used EasyMKL to combine a huge amount of basic kernels alongside a feature selection methodology, pursuing an optimal and sparse solution to facilitate interpretability. Our results show that the proposed approach, called EasyMKLFS, outperforms baselines (e.g. SVM and SimpleMKL), state-of-the-art random forests (RF) and feature selection (FS) methods.

Indexed as

AlgorithmsMachine LearningAlzheimer DiseaseDepressionHumansImage Interpretation, Computer-AssistedNeuroimagingFeature selectionMultiple kernel learningNeuroimaging

Identifiers

PMID30894334
PMCPMC6547052

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.